2022年6月24日 · HLA-B27 and Ankylosing Spondylitis. There are hundreds of HLA genes, each identified by a different number. One gene, HLA-B27, is strongly associated with a big family of rheumatic diseases called spondyloarthropathies. It includes: Axial spondyloarthritis; Axial psoriatic arthritis; Reactive arthritis

Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759) [1] is a class I surface molecule encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells.

2018年6月5日 · HLA-B27 is a genetic test. The majority of people who have a positive HLA-B27 are perfectly healthy. HOWEVER, having a positive HLA-B7 can put you at increased risk of developing what we call spondyloarthritis-associated diseases.

2023年7月4日 · The human leukocyte antigens (HLA) are gene loci in the major histocompatibility complex class I of genes on chromosome 6, present on all nucleated cells. This activity reviews the varied presentations of HLA-B27 associated syndromes.

HLA-B27 is a MHC class I molecule consisting of an alpha chain encoded in the MHC region on chromosome 6 and a non-MHC encoded beta chain, β 2 microglobulin. 26 different alleles have been identified which code for 24 different proteins designated HLA-B*2701–B*2725 (B*2722 was deleted on the discovery that it had the same sequence as B*2706 ...

2019年4月4日 · The strongest link by far is with HLA-B27; certain variations in the HLA-B27 gene are associated with development of AS. Usually HLA genes help your immune system in recognizing and presenting foreign invaders, such as viruses and bacteria, to the immune cells.

Variants in the HLA-B gene, particularly a version called HLA-B27, significantly increase the risk of developing ankylosing spondylitis. This condition is a form of painful, ongoing joint inflammation (chronic inflammatory arthritis) that primarily affects the spine.

The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility. Its prevalence in the mid-European population is about 8%.

However, human leukocyte antigen (HLA)-B27 has been suggested to be important in the pathogenesis of AS, contributing to ~20.1% of AS heritability. The current review will present the classical and non-classical forms of HLA-B27, as well as their pathogenic roles, and further discuss the hypotheses regarding the potential pathogenesis of AS.

2025年3月10日 · The B27 test, also known as the HLA-B27 test, is a blood test used to detect the presence of a specific genetic marker, HLA-B27, in an individual's blood. This test is commonly used to help diagnose and manage certain autoimmune disorders, such as ankylosing spondylitis, reactive arthritis, and other spondyloarthropathies.