The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein [5] in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding.

B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively.

2006年4月15日 · B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity.

We show that the interaction of B7-1 with PD-L1 inhibits T cell activation and cytokine production by comparing responses of T cells deficient in the well-described (CD28, CTLA4, and PD-1) and newly-characterized (B7-1 and PD-L1) receptors to either B7-1-Ig or PD-L1-Ig.

2002年2月1日 · New B7 and CD28 family members and new pathways have recently been identified that seem to be especially important for regulating the responses of previously activated, rather than...

B7-1 (CD80) and B7-2 (CD86) are both type I proteins that are members of the immunoglobulin (Ig) superfamily. 7, 8 B7-1 expression is found on activated B cells, activated T cells and macrophages. 8 B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells and ...

Know comprehensive B7-1/CD80 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

B7–1, also called CD80, is a type I transmembrane protein that exists as a monomer and homodimer . It can be found on antigen presenting cells (APCs), including DCs, B cells, and monocytes [30–33]. It is upregulated on activated APCs [31–33] and …

We show that the cytoplasmic domain from the B7-1 antigen, a commonly used element for mammalian surface display, can enhance the intracellular transport and surface display of chimeric proteins in a Sar1 and Rab1 dependent fashion.

B7-1 and B7-2 are members of the immunoglobulin superfamily and important co-stimulatory ligands for T cells. Expressed on antigen-presenting cells (APC) and activated B cells, B7-1 and B7-2 are ligands for T cell-surface CD28.