Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. [5] Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival.

b7-1/cd80 和 b7-2/cd86 通过与 cd28 或 ctla-4 结合来介导 t 细胞共刺激和共抑制作用。在 t 细胞受体 (tcr) 识别抗原肽/主要组织相容性复合体 (mhc) 后，b7-1/cd80 或 b7-2/cd86 与 cd28 的结合会产生一种促进 t 细胞活化的共刺激信号。

2002年2月1日 · New B7 and CD28 family members and new pathways have recently been identified that seem to be especially important for regulating the responses of previously activated, rather than...

B7-2分子属B7家族成员，主要表达于某些 抗原提呈细胞 表面，能与CD28结合，可提供T细胞活化的 协同刺激信号，与 细胞毒性T淋巴细胞 抗原4 (CTLA-4)结合，可启动抑制性信号，对T细胞活化有负反馈作用。 B7-2分子即CD86，属B7家族成员。

2003年2月26日 · Here, we report the crystal structure of the receptor-binding (Ig V-type) domain of human B7-2 at 2.7-Å resolution. Structures of unliganded and liganded B7-1 and B7-2 suggest a physical–chemical basis for the observed functional similarities and differences between these two costimulatory ligands.

2006年4月15日 · B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity.

2006年4月15日 · B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity.

B7-1 (CD80) and B7-2 (CD86) are both type I proteins that are members of the immunoglobulin (Ig) superfamily. 7, 8 B7-1 expression is found on activated B cells, activated T cells and macrophages. 8 B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells and ...

B7-1 and B7-2 are members of the immunoglobulin superfamily and important co-stimulatory ligands for T cells. Expressed on antigen-presenting cells (APC) and activated B cells, B7-1 and B7-2 are ligands for T cell-surface CD28.

2001年3月29日 · To examine the structural basis for co-stimulation, we have solved the structure of the complex formed by the disulphide-linked homodimer of human CTLA-4 and the receptor-binding domain of human...