B7-H3 (also known as CD276), a member of the B7 family of immune checkpoint proteins, is highly expressed in cancer cells and activated tumor-infiltrating immune cells, and helps cancer cells to evade the surveillance of cytotoxic T-cells and natural killer cells [4].

2022年3月20日 · B7-H3 remains an orphan ligand, although a potential receptor, TLT-2, was detected on activated immune cells 27. B7-H3/TLT-2 was shown to augment chemokine production and proinflammatory cytokine, by activating the phosphorylation of downstream mitogen-activated protein kinase (MAPK) p38 and NF-kappa B p65 28 .

2025年3月13日 · Antibody–drug conjugates (ADCs) have emerged as a transformative modality in the treatment of solid tumors. YL201, a novel B7H3-targeting ADC, leverages a tumor microenvironment activable...

Among them, B7-H3, a member of the B7 ligand family, represents an attractive target for antibody-based immunotherapy: it is overexpressed on differentiated malignant cells and cancer initiating cells, with limited heterogeneity, and high frequency (60% of 25,000 tumor samples) in many different cancer types, but has a limited expression at low ...

2023年11月28日 · B7-H3, B7-H4 and BTN3A1, which are structurally related to the B7 family, have been described as inhibitory ligands that dampen T cell responses by interacting with as of yet unidentified ...

B7-H3 is a highly glycosylated protein. 37 Current evidence shows that the abnormal glycosylation of B7-H3 in tumors is of great significance for protein expression and ligand-receptor binding. 38 Aberrant glycosylation of B7-H3 stabilizes the protein itself, resulting in the accumulation of B7-H3 in tumors, which can be used as an important ...

2022年10月25日 · Many immune checkpoints expressed on the surface of T cells, such as PD-1, CTLA-4, LAG-3, TIGIT, VISTA, and TIM-3, bind to their respective ligands on APCs and/or tumor cells, eliciting positive and/or negative activity in the T cell response. TIM-3 also participates in associated signaling through PtdSer, HMGB-1 and Gal-9 in dying tumor cells.

2007年8月15日 · Expression levels of B7-H3 in prostate cancer were correlated with pathologic indicators of aggressive cancer as well as clinical outcome. We report that B7-H3 is uniformly and aberrantly expressed by adenocarcinomas of the prostate, high-grade prostatic intraepithelial neoplasia, and four prostate cancer cell lines, whereas B7-H1 is rarely ...

2023年7月1日 · B7-H3 expression is induced by the stimulatory effect of anti-programmed death-1 (PD-1), anti-programmed death ligand-1 (PD-L1) or anti-vascular endothelial growth factor (VEGF) on interferon (IFN)-γ signaling, and its increased expression stimulates type 2 macrophage (M2) polarization and increased indoleamine-2,3-dioxygenase 1 (IDO1 ...

2024年1月5日 · These results revealed a new, dimerization-dependent intrinsic tumorigenic signaling role for 4Ig-B7-H3, likely acting in cis, and provide a therapeutically-actionable target for intervention of...