B7-H6分子是近年来发现的新型B7家族成员，可与自然杀伤（NK）细胞活化型受体NKp30特异性结合，介导NK细胞发挥肿瘤免疫杀伤作用。 B7-H6在正常细胞表达中缺失，而在多种肿瘤细 …

B7-H3在正常组织中很少表达，而在大多数恶性肿瘤中异常表达，帮助肿瘤细胞免疫逃逸，同时赋予肿瘤细胞更具攻击性的表型，因此B7-H3高表达与肿瘤侵袭性和不良预后相关。 目前B7-H3 …

2021年4月6日 · Results showed that Tumor B7-H6 expression is highly associated with Her-2 over expression. B7-H6 + immune cells are highly related to the Scarff–Bloom–Richardson …

2025年3月19日 · Interaction of NKp30 with B7-H6 on ILC2s, both in vitro and in vivo, induced the secretion of type 2 cytokines [136, 137]. However, there is also evidence that B7-H6 helps …

The checkpoint protein B7-H6 (NCR3LG1) exhibited increased protein expression relative to PD-L1 in cell lines and tumors (p < 0.05). Higher B7-H6 protein expression correlated with longer …

Abstract: B7H6, also known as NCR3LG1, is the ligand of natural killer cell surface receptor NKp30. NK cells are innate immune cells that play a key role in recognizing and killing tumor …

2022年9月1日 · B7-H6 exhibits two distinct functions, assisting tumor invasion via stimulation of NK-cell-mediated cytotoxicity, which leads to the destruction of normal connective tissue, and …

2022年9月1日 · The B7-H6-NKp30 complex on the tumor membrane activates the NK cells and releases both tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). B7-H6 is …

2024年5月3日 · Here, by screening for mediators of natural killer (NK) cell recognition on T cells, we identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated …

1 B7-H6 会与自然杀伤细胞上的 NKp30 激活受体结合，诱导细胞毒性，从而促进抗肿瘤免疫应答。 1-2 与此相对的是，研究还显示可溶性 B7-H6（可由 ADAM 介导的胞外域脱落产生）与某 …