2021年4月15日 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of …

Beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has historically focused on the brain and its actions as the β‐secretase responsible for the production of amyloid beta …

BACE1 is a typical aspartyl protease with 2 active aspartate motifs (D 93 TG and D 289 SG) located in each lobe. BACE1 is first synthesized in the endoplasmic reticulum as a 501-amino …

2024年12月24日 · BACE1 (Beta-Secretase 1) is a Protein Coding gene. Diseases associated with BACE1 include Alzheimer's Disease and Myositis . Among its related pathways are …

This review discusses the identification and initial characterization of BACE1 and BACE2, and summarizes recent studies of BACE1 knockout mice that have validated BACE1 as the …

BACE1 is a type 1 transmembrane aspartyl protease consisting of 501 amino acids mainly expressed in the neurons. The extraneuronal portion of APP is cleaved by BACE1 to generate …

2007年11月15日 · Here we review BACE1 biology, covering aspects ranging from the initial identification and characterization of this enzyme to recent data detailing the apparent …

2025年3月21日 · Amyloid cerebrovascular disease, primarily driven by the accumulation of amyloid-beta (Aβ) peptides, is intricately linked to neurodegenerative disorders like …

2025年2月26日 · Elevated levels of β-secretase (BACE1), the β-secretase responsible for generating Aβ peptides, lead to aberrant cleavage of GABA A R β1/2/3 subunits in the brains …

2021年4月15日 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of …