2022年3月31日 · Deterioration of BBB form and function is a feature part of healthy aging, but it is worsened in many neurodegenerative disorders and is a hallmark of cognitive decline.

2021年3月15日 · Brain fluid dynamics, pericyte health and basement membrane and glycocalyx compositions are all altered with healthy aging. Carrying the ApoE4 allele leads to an acceleration of most of the BBB’s...

We approached this topic by exploring the causal involvement of the blood-brain barrier (BBB) pathology in age-related brain dysfunction. The BBB is a tightly regulated interface composed of specialized endothelial cells, pericytes, and astrocytic end feet that form a protective sheath around brain capillaries (1, 2).

2024年8月1日 · During aging, the BBB becomes impaired, and it may contribute to the development of neurodegenerative and neurological disorders including Alzheimer’s disease and other dementias. Restoring the BBB can be a strategy to prevent disease onset and development, reducing the symptoms of these conditions.

2023年6月29日 · It has highlighted that aging or neurodegenerative diseases are associated with BBB dysfunction, and importantly, BBB damage can contribute to the progression of these disease processes. Therefore, targeting BBB dysfunction may promote healthy aging and improve neurodegenerative diseases.

2020年7月1日 · These findings reveal the extent of physiological protein transcytosis to the healthy brain, a mechanism of widespread BBB dysfunction with age and a strategy for enhanced drug delivery. To...

2023年2月27日 · This review examines BBB and neurovascular unit changes in normal aging and in neurodegenerative disorders, particularly focusing on Alzheimer disease, cerebral amyloid angiopathy and vascular dementia. Increasing evidence indicates BBB dysfunction contributes to neurodegeneration.

2024年8月15日 · BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of …

These findings establish the endothelial CX43-PARP1-NAD + pathway’s role in vascular aging and identify a potential therapeutic strategy to combat aging-associated BBB leakage with neuroprotective implications.

With the recent connection between the BBB and gut microbiota, microbial-derived metabolites have been explored for their capabilities to protect and restore BBB physiology.