2024年4月17日 · Single-cell RNA-sequencing analysis reveals that brain endothelial cells (bECs), which express high levels of GSDMD, have a prominent response to circulating LPS. LPS acting on bECs primes...

2015年11月25日 · The BBB is relatively resistant to LPS-induced disruption with some brain regions more vulnerable than others. LPS-induced disruption appears is to be dependent on COX but not on oxidative stress. Based on in vivo and in vitro measures of neuroinflammation, it appears that astrocytes, microglia/macr …

2015年11月25日 · Gram-negative endotoxin in its more purified form of lipopolysaccharide (LPS) is known to disrupt the BBB and also alters many other aspects of BBB function, including adsorptive transcytosis, immune cell trafficking, and various transport functions [5–9].

2021年11月4日 · Lipopolysaccharide (LPS), the cell wall component of Gram-negative bacteria, can damage the barrier function of BBB and further promote the occurrence and development of sepsis-associated encephalopathy (SAE).

Cellular responses of BBB evoked by LPS. lipopolysaccharide (LPS) activates Ras homolog family member A (RHOA) and Nuclear factor-k-gene binding (NF-κB), and destroys the tight junctions (TJs) protein by triggering the production of cyclooxygenase-2 (Cox-2); LPS inhibits the expression of Nuclear factor-erythroid 2-related factor 2 (Nrf2 ...

2024年4月18日 · 血脑屏障（Blood–Brain Barrier，BBB）是大脑实质与外周循环系统间的一道保护性天然屏障，由大脑内皮细胞（bEC）与周细胞、平滑肌细胞、星形胶质细胞、小胶质细胞和巨噬细胞共同组成。 血脑屏障允许特定的营养物质从外周循环转运到中枢神经系统（CNS），而阻断不必要或有害物质的进入。 病理性因子或全身性炎症对血脑屏障的破坏，可导致或加剧各种中枢神经系统病变，包括阿尔茨海默病（AD）、渐冻症（ALS）、亨廷顿症（HD）和多发性硬 …

2021年9月30日 · Systemic inflammation induced by intraperitoneal LPS increased the uptake of insulin into the brain independent of BBB disruption through a mechanism involving posttranslational modulation of...

2024年6月4日 · Bacterial lipopolysaccharide (LPS) can disrupt the blood-brain barrier (BBB). This is thought to result mainly from antibacterial responses triggered by activation of the cell-surface LPS receptor Toll-like receptor 4 (TLR4).

2024年4月18日 · 已经有研究发现，革兰氏阴性细菌的重要促炎因子脂多糖（lps），在感染期间或者单独注射的情况下，会引起血脑屏障受损。不过，lps导致血脑屏障 ...

2024年4月19日 · 血脑屏障（Blood-brain-barrier，简称BBB）是维持中枢神经系统正常功能的重要结构，由内皮细胞（endothelial cells）、壁细胞（mural cells）、星形胶质细胞（astroctyes）、小胶质细胞/巨噬细胞（microglia/macrophages）以及神经元（neurons）共同构成，是神经血管单元（neurovascular unit）的特殊性质之一。 血脑屏障的内皮细胞通常不具备允许物质自由通过的开窗结构（fenestration），却拥有致密的紧密连接体（tight junctions）以及特殊的载体介导的 …