YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes.

Moreover, the relationship between YAP1 and PD-L1 revealed the important role of YAP1 in im-munotherapy against NSCLC. Further, preclinical studies reported roles of verteporfin, one drug targeting YAP1, such as inhibition of NSCLC cell proliferation, reduction in cancer stem cell activity, and restoration of treatment sensitivity.

2024年4月26日 · Increased YAP1 protein expression remarkably activated the YAP1/TAZ-TEAD1 signaling pathway, which further boosted the malignant phenotypes in GC cells. In conclusion, these findings highlight...

Yes相关蛋白1 (Yes-associated protein 1，YAP1)是Hippo信号通路 (Hippo pathway)中的一个分子．早期研究人员发现，在Hippo信号通路正常的情况下，YAP1处于非激活状态；当Hippo信号通路中的某些分子出现突变时，YAP1处于超激活状态．此时，超激活状态下的YAP1可以促进细胞增殖 ...

河马信号主要调节Yap1结合 TEA domain family member （TEAD）转录因子的能力。 Yap1通过大的扁平界面与TEAD4紧密结合，这使得小分子正构抑制剂的开发极具挑战性。 在此，我们报道了小分子TEAD·Yap抑制剂，该抑制剂可与位于TEADs独特的深层 疏水性棕榈酸酯结合口袋 中的保守半胱氨酸快速且选择性地形成共价键。 这些化合物抑制TEAD4与Yap1的结合是不可逆的，并且发生的时间更长。 在哺乳动物细胞中，这些化合物与TEAD4形成 共价复合物，抑制了其 …

In this study, by loss-of-function assay, we demonstrated that YAP1 contributed to the glycolytic phenotype of breast cancer cells. Knockdown of YAP1 inhibited the extracellular acidification rates, glucose consumption, and lactate production of breast cancer cells.

人们正在研究 yes 相关蛋白 1 (YAP1)（一种器官大小控制器和机械转导器）是否与炎症诱导的 BPH 有关。 分析了人和大鼠 BPH 标本中 YAP1 表达与纤维化之间的相关性。

2024年12月25日 · YAP1 (Yes1 Associated Transcriptional Regulator) is a Protein Coding gene. Diseases associated with YAP1 include Coloboma, Ocular, With Or Without Hearing …

2022年6月7日 · YAP1（Yes 相关蛋白 1）是通过充当基因表达驱动因子来介导肿瘤发生的主要因素之一。 已被证实在器官体积控制、干细胞功能、组织再生、肿瘤发生和肿瘤转移中发挥重要作用。

2012年12月21日 · Loss-of-function screens and β-catenin activity profiling in 85 cancer cell lines identified a transcriptional complex composed of YAP1, a known mediator of Hippo signaling, the transcription factor TBX5, and β-catenin. This complex is essential for the proliferation and tumorigenicity of β-catenin-active cell lines.