A total of 25 genes in the Bcl-2 family were identified by 2008. Members of the BCL-2 family regulate apoptosis in mammals, reptiles, amphibs, fish, and other phyla of metazoan life, with exception of nematodes and insects. [3]

Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) [5] while other BCL2 family members can either inhibit or induce it. [6][7] It was the …

2017年11月17日 · The BCL-2 family is divided into three groups based on their primary function (1) anti-apoptotic proteins (BCL-2, BCL-X L, BCL-W, MCL-1, BFL-1/A1), (2) pro-apoptotic pore-formers (BAX, BAK, BOK...

Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy.

The Bcl-2 family of proteins is formed by pro- and antiapoptotic members. Together they regulate the permeabilization of the mitochondrial outer membrane, a key step in apoptosis. Their complex network of interactions both in the cytosol and on ...

The Bcl-2 family is defined by homology shared within four conserved regions in Bcl-2, termed BCL-2 homology (BH) domains, and is grouped into three subfamilies depending on their apoptotic properties, i.e. the pro-apoptotic Bax- and BH3 …

2019年2月21日 · BCL-2 family members play an integral role in apoptosis, but also contribute to many other cellular functions. Isoforms of almost all of the BCL-2 family members have been identified and some...

2023年7月12日 · In this Review, we revisit the most important advances in the field and integrate them into a new structure–function-based classification of the BCL-2 family members that intends to provide...

2008年7月1日 · Here, we discuss the mechanisms by which Bcl-2 family members, well-characterized regulators of apoptosis, also regulate autophagy. Bcl-2 is the prototype of a family of proteins containing at least one Bcl-2 homology (BH) region.

1999年8月1日 · Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins.