2005年12月25日 · In this report we characterize the molecular and cellular responses of Cd45−/− B cells to BCR ligation, defining defects in the activation of Erk1 and Erk2 mitogen-activated …

B 细胞抗原受体 (BCR) 由细胞膜免疫球蛋白 (mIg) 分子和相关的 Igα/Igβ (CD79a/CD79b) 异二聚体 (α/β) 组成。 mIg 亚单位结合抗原，导致受体聚集，同时 α/β 亚单位将信号转导至细胞内部。

Although high expression of CD45 inhibits T-cell receptor (TCR) signaling, we show that CD45 plays a purely positive regulatory role during B-cell receptor (BCR) signaling. In concert with …

2022年3月1日 · CD45 (also known as PTPRC), a receptor-type protein tyrosine phosphatase, plays an essential role in both BCR and T cell receptor (TCR) signaling by activating Src family …

2018年8月17日 · We propose that galectin-9 organizes IgM-BCR into larger clusters that restrict the mobility of IgM and relocalizes inhibitory molecules, including CD45 and CD22 to directly …

Although high expression of CD45 inhibits T-cell receptor (TCR) signaling, we show that CD45 plays a purely positive regulatory role during B-cell receptor (BCR) signaling.

CD45是免疫细胞信号传导途径的重要调节因子：在T细胞和B细胞中，CD45通过调节Src家族激酶的活性，影响TCR和BCR的信号传导，而CD45的缺失会导致T细胞和B细胞的发育障碍，以及 …

2023年9月20日 · 2023年8月31日，宾夕法尼亚大学Saar Gill 教授、Carl June 教授研究团队在Science 子刊 Science Translational Medicine 上发表了题为Epitope base editing CD45 in …

BCR ligation of Cd45-/- B cells failed to activate phosphatidylinositol-3-OH kinase, NF-kappaB, Erk1 or Erk2 kinases or to upregulate cell survival proteins and instead induced apoptosis. …

1997年2月1日 · Expression of the phosphotyrosine phosphatase CD45 is essential for B cell Ag receptor (BCR)-mediated p21ras activation and calcium mobilization. To examine the …