More analytically, the BCR complex consists of an antigen-binding subunit known as the membrane immunoglobulin (mIg), which is composed of two immunoglobulin light chains …

2025年2月26日 · The B cell receptor (BCR) complex is a protein structure composed of mIg and signaling subunits Igα/Igβ. The complete BCR complex consists of six chains: two mIg heavy …

2000年7月1日 · The B cell antigen receptor (BCR) plays a central role in the development, survival, and activation of B lymphocytes. The BCR is a multiprotein complex consisting of the …

2022年9月15日 · The BCR is composed of homodimeric membrane-bound immunoglobulin (mIg) that confers antigen specificity (IgD and IgM expressed by mature naïve B cells; IgG, IgA and …

B细胞抗原受体复合体（简称BCR复合体）由B细胞抗原受体（B cell receptor, BCR）和Igα-Igβ组成。 BCR既是表达于成熟B细胞膜表面的IgM（mIgM）和IgD（mIgD），是B细胞特有的抗原 …

In this review, we will discuss three major BCR mediated signaling pathways (the PLC-γ2 pathway, PI3K pathway and MAPK pathway) and related regulators, which were roughly …

2025年2月13日 · B-cell receptor (BCR) complexes are expressed on the surface of a B-cell and are critical in antigen recognition and modulating the adaptive immune response.

BCR consists of two immunoglobulin heavy chains (Igα and Igβ) and two light chains (mIg), forming a heterodimer complex. Among them, mIg is the key part of antigen recognition, which …

To solicit T cell help, the BCR captures the antigen and delivers it to intracellular vesicles for proteolytic processing and loading onto major histocompatibility complex class II (MHC II) …

2025年1月12日 · The B cell receptor complex is a sophisticated molecular assembly integral to the immune system’s ability to recognize and respond to antigens. At its core, the BCR is …