2024年12月24日 · BCR (BCR Activator Of RhoGEF And GTPase) is a Protein Coding gene. Diseases associated with BCR include Leukemia, Chronic Myeloid and B-Lymphoblastic Leukemia/Lymphoma With T(9;22)(Q34.1;Q11.2) . Among its related pathways are Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics and RHOC GTPase cycle .

The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome .

BCR基因（英語： BCR gene ），或称断裂点簇集区（英語： breakpoint cluster region ），是bcr-abl融合基因的组成部分之一，其与费城染色体的形成机制有关。

The BCR gene provides instructions for making a protein whose function is not completely understood. Studies show that the BCR protein may act as a GTPase activating protein (GAP). GAPs turn off (inactivate) proteins called GTPases, which play an important role in chemical signaling within cells.

This review explores the mechanisms behind cancer progression of these BCR oncogenic fusion proteins, comparing their similarities and differences, examining the significance of BCR as a partner gene, and discussing current treatment options for these translocation-induced hematopoietic malignancies.

BCR基因 （英语： BCR gene ），或称 断裂点簇集区 （英语： breakpoint cluster region ），是 bcr-abl融合基因 的组成部分之一，其与 费城染色体 的形成机制有关。

2001年3月3日 · Recent investigations have rapidly added crucial new insights into the complex functions of the normal BCR gene and of the BCR-ABL chimera and are yielding potential therapeutic breakthroughs in the treatment of Philadelphia (Ph) chromosome-positive leukemias.

2023年12月20日 · The Bcr gene, also known as the breakpoint cluster region gene, plays a significant role in the development and progression of certain diseases, particularly Philadelphia chromosome-positive leukemias. This gene is located on chromosome 22 and is involved in a specific genetic abnormality known as the Bcr-Abl translocation.

2025年3月3日 · BCR-ABL1 is an abnormal gene present in certain types of leukemia. Genetic testing for BCR-ABL1 helps doctors diagnose these cancers and assess their response to treatment. If you or someone you ...

2016年9月14日 · Gene target information for BCR - BCR activator of RhoGEF and GTPase (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.