2025年3月5日 · A mechanistic study reveals that RBPMS suppresses bladder cancer cell migration by regulating alternative splicing of ANKRD10, which modulates MYC pathway activity through ANKRD10-2’s function ...

2025年3月6日 · 为探究膀胱癌（blca）发展机制，研究人员聚焦 rna 结合蛋白 rbpms，发现其可抑制 blca 转移，意义重大。 RBPMS 抑制膀胱癌转移新机制：调控 ANKRD10 可变剪接，影响 MYC 通路 - 生物通

2025年3月9日 · 2025年2月25日，重庆医科大学孙阳，黄荣忠和昆明理工大学蒋立虹共同通讯在PNAS在线发表题为“The RNA-binding protein RBPMS inhibits smooth muscle cell–driven vascular remodeling in atherosclerosis and vascular injury”的研究论文。 该研究发现RNA结合蛋白、mRNA加工因子（RBPMS）是一个保守的、VSMC特异性的基因，与动脉粥样硬化中的VSMC调制相关. 在人类和小鼠的动脉粥样硬化动脉中，以及在损伤后内膜增生阶段的两个血管损伤模型 …

Our systems biology approach identified RNA binding protein, mRNA processing factor (RBPMS) as a conserved, VSMC-specific gene associated with VSMC modulation in atherosclerosis. RBPMS gene expression positively correlates with VSMC contractile markers in human and murine atherosclerotic arteries as well as in two vascular injury models during ...

Numerous RNA-binding proteins (RBPs) are expressed in the heart, and mutations in several RBPs have been implicated in cardiovascular disease through genetic associations, animal modeling, and mechanistic studies. However, the functions of many more cardiac RBPs, and their relevance to disease states, remain to be elucidated.

2022年4月25日 · We show that the genetic deletion of RNA-binding protein with multiple splicing (Rbpms), an uncharacterized RNA-binding factor, causes perinatal lethality in mice due to congenital cardiovascular defects. The loss of Rbpms causes premature onset of cardiomyocyte binucleation and cell cycle arrest during development.

本研究使用两种选择标记 Brn3a 和 RBPMS 检查手动 RGC 计数的准确性。 方法：使用 Brn3a 和/或 RBPMS 抗体对 1 至 18 个月大的 C57BL/6 小鼠以及微珠 (MB) 诱导眼内压 (IOP) 升高后的小鼠的视网膜平片进行免疫染色。

测序分析表明，rbpms 在 rna 剪接中发挥作用，并影响参与细胞骨架信号传导途径的 rna。 我们发现 RBPMS 介导富含心脏的 LIM 结构域蛋白Pdlim5的异构体转换。

为了解决细胞特异性调节因子如何在选择性剪接调节中与组成型 RBP 协作，我们使用了平滑肌特异性调节因子 RBPMS。 重组 RBPMS 足以通过阻止 ATP 依赖性剪接复合物的组装，在无细胞测定中赋予平滑肌细胞特异性 Tpm1 外显子 3 选择性剪接。 该活性依赖于 C 端 IDR，促进动态高阶自组装、与多价 RNA 的协同结合以及与广泛表达的剪接共调节因子（包括 MBNL1 和 RBFOX2）的相互作用，从而允许稳定的细胞特异性调节复合物的协同组装。

RBPMS (RNA Binding Protein, MRNA Processing Factor) is a protein coding gene located on human chromosome 8p12. RBPMS is also known as HERMES. The human RBPMS gene encodes a 21802 Da protein containing 196 amino acids. The RBPMS protein is ubiquitously expressed in prostate, ovary and other tissues.