Brain-derived neurotrophic factor (BDNF) has emerged as a regulator of stable, late phase long-term potentiation (L-LTP) at excitatory glutamatergic synapses in the adult brain. However, the …

One of the downstream genes induced by the L-LTP-inducing tetanus is BDNF. BDNF is a small dimeric protein that works through high affinity binding with the receptor tyrosine kinase, …

The role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin acts at pre- and post-synaptic levels. Recent studies have shown that BDNF regulates the transport of …

In addition, studies also show that BDNF is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions. The effects of …

The effects of brain-derived neurotrophic factor (BDNF) in long-term synaptic potentiation (LTP) are thought to underlie learning and memory formation and are partly mediated by local …

2016年2月18日 · Acute BDNF infusion induced long-term potentiation (LTP) of medial perforant path-evoked synaptic transmission and, concomitantly, enhanced hippocampal neurogenesis …

2014年1月1日 · Local protein synthesis induced by BDNF contributes to long-term synaptic plasticity and memory formation. Brain-derived neurotrophic factor (BDNF) is an important …

2014年1月1日 · With a focus on how BDNF signaling controls L-LTP, we distill and discuss the latest advances along three main lines: 1) tropomyosin-like kinase B (TrkB) receptor-coupled …

2021年10月20日 · 而神经元来源的 bdnf 对 e-ltp 和 l-ltp 都很重要。 进一步的机制研究表明，两类细胞释放 BDNF 的动力学差异可能是导致不同形式 LTP 的原因。 并且，不同细胞来源的 …

2021年12月27日 · In this review, we examine the importance of spatial and temporal factors on BDNF activity, particularly in processes such as synaptogenesis, Hebbian plasticity, …