Beclin-1 is a protein that in humans is encoded by the BECN1 gene. [5] [6] Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. [7] This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.

2024年12月24日 · BECN1 (Beclin 1) is a Protein Coding gene. Diseases associated with BECN1 include Sphingolipidosis and Pancreatic Ductal Adenocarcinoma. Among its related pathways are Early SARS-CoV-2 Infection Events and Autophagy. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and phosphatidylinositol 3-kinase binding.

2019年8月21日 · 加州大学的研究人员在新研究中揭示了一个调控细胞自噬的关键分子机制，他们发现一种称作ULK1的激酶通过磷酸化Beclin-1，激活脂酶VPS34，诱导了细胞自噬发生. 这篇文章中研究人员证实，当氨基酸缺乏或mTOR抑制时，激活的ULK1会磷酸化Beclin-1的Ser 14位点，由此提高VPS34复合体活性。 通过ULK导致Beclin-1 Ser 14位点磷酸化是哺乳动物充分诱导自噬的必要条件. beclin1有一个BH3结构域，bcl2等可以通过BH3结构域与beclin1结合而影响其活性。

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3-Kinase (PI3K) complexes to generate phosphorylated phosphatidylinositol (PtdIns), lipids essential for not only autophagy but other membrane trafficking processes.

2025年2月19日 · Genome-wide shRNA screening identifies BECN1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells: PubMed: nef: HIV-1 Nef acts as an antiautophagic maturation factor through interaction with the autophagy regulatory factor Beclin 1, leading to protect HIV-1 from degradation: PubMed: capsid: gag

2025年3月3日 · Using conditional gene knockout mouse models, we demonstrated that loss of Beclin 1 (Becn1), a major regulator of mammalian autophagy, exclusively in the megakaryocytic lineage disrupted...

2024年12月5日 · This report outlines the findings of all the existing research on the role of SNPs within BECN1. Autophagy is a cytoprotective process that operates within a cell to maintain cellular homeostasis. An array of multiple proteins is involved to mediate th

编码的蛋白质是磷脂酰肌醇 3 激酶 (PI3K) 复合物的一个组分，该复合物介导囊泡运输过程。 这种蛋白质被认为在多种细胞过程中发挥作用，包括肿瘤发生、神经变性和细胞凋亡。 可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月] This gene encodes a protein that regulates Autophagy, a catabolic process of degradation induced by starvation.

2023年3月21日 · Beclinl基因也称BECN1基因，是一种自噬相关基因，它与Bcl-2基因相互拮抗调控自噬。 自噬是细胞中初级溶酶体处理内源性底物的重要过程，同时参与维持细胞内蛋白…

BECN1 protein expression is associated with poor survival in triple negative locally advanced breast cancer. Expression and mechanism of autophagy gene Beclin1 in tumor microenvironment of renal cell carcinoma. Beclin-1 overexpression regulates NLRP3 activation by promoting TNFAIP3 in microvascular injury following myocardial reperfusion.