2024年2月16日 · Tetrahydrobiopterin or Bh4 is a precursor to dopamine, nitric oxide, and serotonin. Learn how to make more Bh4 as well as how it works in the body.

Tetrahydrobipterin (BH4) is a pivotal enzymatic cofactor required for the synthesis of serotonin, dopamine and nitric oxide. BH4 is essential for numerous physiological processes at periphery and central levels, such as vascularization, inflammation, glucose homeostasis, regulation of oxidative stress and neurotransmission.

四氢生物蝶呤（tetrahydrobiopterin）是一种天然存在的营养素，简写为BH4。 是参与5-羟色胺、 多巴胺 、 去甲肾上腺素 、肾上腺素、褪黑素、一氧化氮生物合成的酶的重要辅助因子 [2] ；

2021年6月1日 · Tetrahydrobiopterin (BH 4) deficiency is caused by genetic variants in the three genes involved in de novo cofactor biosynthesis, GTP cyclohydrolase I (GTPCH/ GCH1), 6-pyruvoyl-tetrahydropterin synthase (PTPS/ PTS), sepiapterin reductase (SR/ SPR), and the two genes involved in cofactor recycling, carbinolamine-4α-dehydratase (PCD/ PCBD1) and di...

2018年9月28日 · Tetrahydrobiopterin (BH4) deficiencies are disorders that affect phenylalanine (Phe or F) homeostasis, as well as brain biosynthesis of catecholamine, serotonin, and...

2024年5月18日 · The GCH1 gene, which is the first step in the synthesis of BH4, is expressed in T cells. When T cells are activated, GCH1 is induced and BH4 levels increase. Researchers discovered that inhibiting GCH1 reduced the number of activated T cells.

Tetrahydrobiopterin (BH₄) deficiency is caused by genetic variants in the three genes involved in de novo cofactor biosynthesis, GTP cyclohydrolase I (GTPCH/GCH1), 6-pyruvoyl-tetrahydropterin synthase (PTPS/PTS), sepiapterin reductase (SR/SPR), and the two genes involved in cofactor recyc …

2018年11月7日 · We find that genetic inactivation of GTP cyclohydrolase 1 (GCH1, the rate-limiting enzyme in the synthesis of BH4) and inhibition of sepiapterin reductase (the terminal enzyme in the synthetic...

2004年11月19日 · BH4-responsive PAH deficiency is a variant of hyperphenylalaninemia or phenylketonuria (PKU) caused by mutations in the human PAH gene that respond to oral BH4 loading by stimulating enzyme activity and therefore lowering serum phenylalanine.

2015年7月28日 · BH4 is an essential cofactor for three aromatic amino acid hydroxylases, including tyrosine hydroxylase (rate-limiting enzyme in dopamine biosynthesis), tryptophan hydroxylase (TPH2), and phenylalanine hydroxylase (PAH), as well as three isoforms of nitric oxide synthase (NOS), which catalyses the synthesis of nitric oxide from arginine, and ...