Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31. [5] [6]

2024年12月25日 · CUSABIO Human Transforming growth factor-beta-induced protein ig-h3 (TGFBI/BIGH3) ELISA kit

BIGH3（TGFBI，Transforming Growth Factor Beta-Induced Protein）是一种与细胞外基质和细胞黏附密切相关的蛋白质，在细胞生物学和生物医学研究中具有重要意义。 本文将介绍BIGH3重组蛋白的结构、功能以及其在生命…

2023年12月1日 · BIGH3（TGFBI，Transforming Growth Factor Beta-Induced Protein）是一种与细胞外基质和细胞黏附密切相关的蛋白质，在细胞生物学和生物医学研究中具有重要意义。 本文将介绍BIGH3重组蛋白的结构、功能以及其在生命科学和医学领域的潜在应用。

2024年10月17日 · 本研究选用了敲低效果较好的si-BIGH3#2小干扰RNA以及过表达质粒进一步对HCT116和SW620细胞系进行基因敲低与上调，并通过克隆形成、划痕实验以及transwell实验等功能实验进一步探究BIGH3基因对结直肠癌细胞生物学行为的影响。

2015年11月1日 · BIGH3, also known as TGFBI (Transforming growth factor-β-induced), encodes a 68-kDa protein expressed in most human tissues, but not in the brain (Skonier et al., 1992, LeBaron et al., 1995, Bae et al., 2002, Ferguson et al., 2003). BIGH3 is secreted and accumulates in the extracellular matrix (ECM).

BIGH3, a secreted protein of the extracellular matrix interacts with collagen and integrins on the cell surface. BIGH3 can have opposing functions in cancer, acting either as tumor suppressor or promoter by enhancing tumor progression and ...

2016年8月26日 · TGFβ induced a significant increase in BIGH3 mRNA and protein expression, and HRP apoptosis. BIGH3 treatment showed HRP undergo apoptosis in a dose-dependent manner.

2024年8月1日 · We also demonstrate that BIGH3 reduces Cx43 expression, blocking gap junction (GJ) function and osteocyte network communication. BIGH3-mediated GJ inhibition is blocked by the lysosomal inhibitor hydroxychloroquine (HCQ), but not osteoanabolic agents.

The extracellular matrix protein transforming growth factor-β (TGF-β) inducible gene H3 (BIGH3) is involved in adhesion and migration, although the effect of BIGH3 is highly cell type-dependent. BIGH3 is abundantly expressed by mesenchymal stromal cells, while its expression in HSPCs is relatively low unless induced by certain BM stressors.