2024年12月24日 · BIRC3 (Baculoviral IAP Repeat Containing 3) is a Protein Coding gene. Diseases associated with BIRC3 include Lymphoma, Mucosa-Associated Lymphoid Type and Lymphoma, Non-Hodgkin, Familial. Among its related pathways are TNFR1 Pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade.

Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene. [5] [6] cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases.

BIRC3 和 BIRC5 已在一些实体瘤和血液肿瘤中得到表征，并且是称为“Smac 模拟物”的药物家族的治疗靶点。 许多证据表明 BIRC3 在癌细胞中的促生存和抗凋亡作用，然而，并非所有数据都是一致的，并且结果是异质的。

预测该基因编码的蛋白可使半胱氨酸型内肽酶抑制剂活性参与细胞凋亡过程和泛素蛋白连接酶活性。 参与多个过程，包括坏死过程；坏死过程的负调控；活性氧代谢过程的负调控。 在肿瘤坏死因子的细胞反应上游或细胞反应内起作用；蛋白质多聚泛素化的正调控；和 NIK/NF-kappaB 信号的调节。 预测位于胞质溶胶中；膜筏；和核质。 预计是含蛋白质复合物的一部分。 预计在细胞 …

2021年1月7日 · BIRC3 (cellular IAP2) and BIRC5 (survivin) are two of the eight members of the human IAPs family. This family is characterized by the presence of the baculoviral IAP repeat (BIR) domains, involved in protein-protein interactions.

BIRC3 is a prognostic marker in Glioblastoma multiforme, Kidney renal papillary cell carcinoma, Lung adenocarcinoma

2023年6月8日 · Differential regulation by cytokines and glucocorticoids shows BIRC2 protein expression to be consistent with roles in rapid signaling events, whereas cytokine-induced BIRC3 may be more important in later effects. While TNF-induced degradation of both BIRCs may restrict their activity, cytokine-enhanced BIRC3 expression could prime for its ...

birc3 （baculoviral IAP repeat containing 3） 该基因编码IAP蛋白家族的一个成员，通过结合肿瘤坏死因子受体相关因子traf1和traf2抑制凋亡，可能通过干扰类冰蛋白酶的激活。

BIRC3的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因，可能是由与ICE样蛋白酶的激活干扰编码IAP家族通过结合肿瘤坏死因子受体相关因子TRAF1和TRAF2抑制细胞凋亡蛋白质的成员。 所编码的蛋白质抑制凋亡的血清剥夺诱导，但不影响所得从暴露于甲萘醌，自由基的有效诱导凋亡。 它包含3个杆状病毒IAP重复和无名指域。 编码相同同 …

BIRC3 (cellular IAP2) and BIRC5 (survivin) are two of the eight members of the human IAPs family. This family is characterized by the presence of the baculoviral IAP repeat (BIR) …