Bilateral and right DLPFC, and mPFC/ACC are the most effective areas to be stimulated in the TMS treatment of OCD. However, the left DLPFC, SMA, and OFC stimulation results are heterogeneous. Moreover, TMS in OCD patients with low SSRI resistance (stage 1 or 2), in other words, in the early stages of the course of the illness, is more effective ...

Thus, this study investigated changes in neuroplasticity in the left dorsolateral prefrontal cortex (DLPFC) before and after the 30 sessions of BL-intervention over a 6-week for TRD. We also examined differences in neuroplastic changes between BL-rTMS and BL-TBS and between responders and non-responders to BL-TMS.

The dorsolateral prefrontal cortex (DLPFC or DL-PFC) is an area in the prefrontal cortex of the primate brain. It is one of the most recently derived parts of the human brain. It undergoes a prolonged period of maturation which lasts into adulthood. [1] The DLPFC is not an anatomical structure, but rather a functional one.

2024年10月8日 · 传统的抑郁症脑刺激疗法通常采用已知的基于头皮的启发式方法来 确定左侧背外侧前额叶皮层 (DLPFC)的单一通用TMS靶点。 其中一种方法将DLPFC的TMS靶点定位在运动皮层前方5至6厘米处,但研究发现这种方法经常完全错过DLPFC,从而导致了Beam F3启发式方法的开发, 该方法估计额叶F3电极的大致位置。 虽然这些方法成本低廉且可以快速实施,但它们导致个体间靶向皮质部位存在显著差异 (图1A)。 这些方法没有考虑神经解剖和脑网络结构的个体差异, 可能 …

In this project we studied spatially resolved and single nucleus transcriptomics data from the dorsolateral prefrontal cortex (DLPFC) from postmortem human brain samples. From 10 neurotypical controls we generated spatially-resolved transcriptomics data using using 10x Genomics Visium across

2023年8月1日 · Evidence for repetitive transcranial magnetic stimulation (rTMS) for smoking cessation is increasing. One rTMS coil has recently received regulatory approval, signaling the potential for clinical adoption. Implementation and dissemination into clinical practice requires planning and preparation.

There are 3 preferred target sites for stimulation i.e., low-frequency right DLPFC (most effective), high-frequency bilateral DLPFC, and low-frequency supplementary motor area (SMA). High-frequency bilateral DLPFC (SMD: 1.52) and low-frequency right DLPFC (SMD:.83) stimulations have reported the most global improvements.

2022年9月15日 · 近日， Nenad Sestan, Andre Sousa和Stephen Strittmatter 团队 评估了来自成年人类、黑猩猩、猕猴和狨猴dlPFC的超过60万个单核转录组，并将其最新研究成果“ Molecular and cellular evolution of the primate dorsolateral prefrontal cortex ”发表在 Science 杂志上。 类人猿类灵长类动物dlPFC细胞的 转录组学 分类. 作者对来自男性和女性，黑猩猩，恒河猴猕猴和普通狨猴成年死后的dlPFC进行了snRNA-seq（图1A）。

人脑前额叶皮层(prefrontal cortex,PFC)被认为是负责认知,情绪和行为管理的高级区域.PFC包括三个子区:背外侧前额叶皮层(dorsolateralprefrontalcortex,DLPFC),腹内侧前额叶皮层(ventromedial prefrontal cortex,VMPFC)和眶额皮层(orbitofrontal prefrontal cortex,OFPFC).其中DLPFC是执行控 …

2024年4月1日 · We found that excitatory stimulation of the bilateral DLPFC, inhibitory stimulation of the right DLPFC, excitatory and inhibitory stimulation of the mPFC/ACC and inhibitory stimulation of bilateral SMA were significantly more effective than sham stimulation in …