Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene. Osteonectin is a glycoprotein in the bone that binds calcium.

Secreted protein acidic and rich in cysteine (SPARC), also named as osteonectin or BM-40, is an acronym for “secreted protein, acidic and rich in cysteine”. Mature human SPARC shows 92%, 92%, 97%, 99%, 96% and 85% aa identity with mouse, rat, …

1999年12月1日 · The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously-folding and crystallisable domain that binds calcium and collagen IV

2006年4月15日 · BM-40, also known as SPARC or osteonectin, is a secreted glycoprotein present in all metazoa. The protein is expressed in tissues undergoing morphogenesis, remodeling, and repair. In vitro, BM-40 binds to several collagens and is both antiproliferative and counteradhesive.

BM-40（Osteonectin，SPARC）是人类成骨细胞分泌的最丰富的糖蛋白。 对小鼠组织中BM-40 mRNA表达进行的原位杂交研究表明，骨骼中转录本的水平最高，但在其他一些间充质组织中也观察到了表达。

骨粘连蛋白（ON）也被称为富含半胱氨酸的酸性分泌蛋白（SPARC）或基底膜蛋白40（BM-40），是一种在人类中由SPARC基因编码的蛋白质。 骨粘连蛋白是一种40 kDa的酸性和富含半胱氨酸的糖蛋白，与钙结合，由一条多肽链组成，可分成4个结构域：氨基端富含谷氨酸区域附近的Ca2+结合域（域I）、富含半胱氨酸的域（域II）、亲水区域（域III）和羧基端区域的EF手图案（域IV）。 它在骨形成过程中由成骨细胞分泌，启动矿化并促进矿物晶体形成。 除了骨矿物质钙 …

SPARC (Secreted ProteinAcidic and Rich in Cysteine) is a prototype of a family of biologically active glycoproteins that bind to cells and to extracellular matrix (ECM) components. It is expressed spatially and temporally during embryogenesis, tissue remodeling and repair.

BM-40 (also known as SPARC or osteonectin) is an anti-adhesive secreted glycoprotein involved in tissue remodelling. Apart from an acidic N-terminal segment, BM-40 consists of a follistatin-like (FS) domain and an EF-hand calcium-binding (EC) domain. Here we report the crystal structure at 3.1 A resolution of the FS-EC domain pair of human BM-40.

SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin or BM-40) is a widely expressed profibrotic protein with pleiotropic roles, which have been studied in a variety of conditions. Notably, SPARC is linked to human obesity; SPARC derived from adipose tissue is associated wi …

Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or BM-40, is the prototypical matricellular protein. Matricellular proteins are nonstructural secreted proteins that provide an integration between cells and their surrounding extracellular matrix (ECM).