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2021年7月3日 · 本文介绍了任务态fMRI与静息态fMRI的区别，任务态侧重于执行任务时的模型驱动分析，如GLM+HRF，而静息态则更注重数据驱动的特征，如功能连接、ReHo和ALFF。 ReHo衡量局部一致性，ALFF探测低频波动强度，有助于理解大脑活动模式和自发活动的特性。 | 图源. 任务态和静息态是大脑的两种状态，前者主要是指大脑在执行记忆、识别以及运动等具体任务时的状态，静息态则是指大脑不执行具体认知任务、保持安静、放松、清醒时的状态，是大脑所处的 …

2012年12月15日 · What I found is that there was a freakishly massive difference in both fALFF and ALFF (FDR q.000000000000 etc.). ALFF was in the same direction as the mfALFF difference and fALFF was in the opposite direction. These are all gray matter masked.

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ALFF的全称为the Amplitude of Low Frequency Fluctuations, 汉语译为低频振幅。 之所以是低频，是因为Biswal的研究证明，运动皮层之间自发的低频（<0 xss=removed>）具有高度同步性[1]，这种高同步性也在正常人的其他功能系统之间被发现。 因此，认为低频（<0 xss=removed>）信号具有生理意义。 此外，研究发现，灰质的低频振幅高于白质，表明ALFF可能会提示局部自发神经元活动。 根据臧玉峰老师的文章[2]可知，预处理后，对每个体素的时间 …

ALFF is calculated as the amplitude of the time series in a certain frequency band, which is the averaged square root of the power spectral density of the filtered time series. To increase the stability of ALFF across subjects, fALFF was proposed as calculating the fraction of a certain frequency band against the whole available frequency band.

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2015年6月8日 · Low-frequency fluctuation of the blood-oxygen-level-dependent (BOLD) signal is an important characteristic of the resting-state brain [1 – 5]. It reflects the strength of brain activity.

2012年1月13日 · ALFF是臧玉峰教授等人基于前人研究的基础上，通过计算低频段（0.01HZ-0.08HZ）下BOLD信号的功率谱的均方根，利用低频信号的能量来表示不同脑区神经元的活动强弱，进而去探讨这种活动下所隐藏的生理意义。 虽然ALFF在一定程度上可以标志神经元活动的强弱，但是它也存在着一定的缺陷，比如：由于噪声的作用，大脑中的脑矢位置会呈现很大的能量，但是它的这种表征并不具有一定的生理意义。 基于上述ALFF存在的缺陷，邹启红等人于2008年 …

Amplitude of low-frequency fluctuation (ALFF) has been widely used for localization of abnormal activity at the single-voxel level in resting-state fMRI (RS-fMRI) studies. However, previous ALFF studies were based on fast Fourier transform (FFT-ALFF).