人骨髓（BM）和脐血（UCB）单细胞转录组揭示红细胞连续分化 …
2020年9月27日 · 使用原代人类终末红系细胞对直接从成人骨髓（BM）和脐带血（UCB）中分离出来的细胞进行单细胞RNA测序（scRNA-seq）（CD34 - CD235a +），本研究以前所未有的分 …
HBB Gene - GeneCards | HBB Protein | HBB Antibody
2024年12月25日 · HBB (Hemoglobin Subunit Beta) is a Protein Coding gene. Diseases associated with HBB include Sickle Cell Disease and Beta-Thalassemia, Dominant Inclusion …
Erythroid lineage chromatin accessibility maps facilitate ...
2023年6月14日 · NFIX knockdown in BM cells increased HBG mRNA and fetal hemoglobin (HbF) protein levels, coincident with increased chromatin accessibility and decreased DNA …
In vivo hematopoietic stem cell modification by mRNA delivery
2023年7月27日 · Hematopoietic stem cells (HSCs) reside in the bone marrow (BM), where they divide throughout life to produce all cells of the blood and immune system through their self …
HBB hemoglobin subunit beta [ Homo sapiens (human) ]
2025年3月8日 · The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists …
Hbb gene - functions, mutations, and implications - Genetics
2023年12月20日 · The Hbb gene, also known as the hemoglobin beta gene, plays a crucial role in oxygen transport within the body. Hemoglobin, a protein made up of four subunits, is …
Bone-marrow-homing lipid nanoparticles for genome editing in …
2024年5月23日 · Here we report on a series of bone-marrow-homing lipid nanoparticles that deliver mRNA to a broad group of at least 14 unique cell types in the bone marrow, including …
HBB protein expression summary - The Human Protein Atlas
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains …
Base editing of haematopoietic stem cells rescues sickle cell …
2021年6月2日 · We used a custom adenine base editor (ABE8e-NRCH) 2, 3 to convert the SCD allele (HBBS) into Makassar β-globin (HBBG), a non-pathogenic variant 4, 5. Ex vivo delivery …
β地中海贫血模型——Hbb-bs&Hbb-bt DKO小鼠 - biomart.cn
2023年12月13日 · Hbb-bs&Hbb-bt DKO小鼠是利用基因编辑技术同时敲除C57BL/6J小鼠Hbb-bs基因和Hbb-bt基因所构建的β地中海贫血疾病模型。该模型纯合致死，杂合小鼠呈现血红蛋白含 …
- 某些结果已被删除