2002年10月28日 · Sprouty (Spry) inhibits signalling by receptor tyrosine kinases; however, the molecular mechanism underlying this function has not been defined. Here we show that after stimulation by growth...

2024年4月26日 · Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinase (RTK) signaling conserved from flies to humans [1]. In mice, Spry genes mainly antagonize signaling by...

2004年6月1日 · Four mammalian homologues (SPRY1, 2, 3 and 4) have been identified, all of which have been implicated in the modulation of RTK signalling. All SPRY proteins have a conserved carboxy-terminal...

There are four mammalian orthologs (Spry1-4) whose modulation of RTK-induced signaling pathways is growth factor- and cell context-dependent. Endothelial cells are a group of highly differentiated cell types necessary for defining the mammalian vasculature.

2012年6月7日 · First, among 4 Spry genes, Spry1 is selectively highly expressed in developing primary bone marrow (pro)erythroblasts. Second, via a conditional loss-of-function approach, Spry1 is indicated to be functionally important in regulating balanced levels of erythroid progenitors versus differentiating erythroblast progeny, especially during anemia.

此外，已有研究确定了BRAF V600E突变（BM）CRC的两种转录亚型BM1和BM2；其中BM1以KRAS/AKT通路激活、可介导侵袭转移、化疗耐药和免疫反应增强的 上皮-间质转化 （EMT）为特征，其预后较BM2型更差。 而BM2型则表现为 细胞周期检查点 异常。 细胞系实验显示，BM1 CRC对BRAF和MEK抑制更敏感，而BM2对CDK抑制剂更敏感。 因此，只有结合分子层面特定的转录和免疫学背景，才可以分析得出特定CRC的生物学特性以及药敏性。

非磷酸化的Spry突变体不能结合Grb2并充当显性负离子，从而诱导ERK响应FGF延长活化，并促进FGF诱导PC12细胞中神经突的生长。 我们的发现表明Spry在负反馈机制中起作用，在该机制中，其抑制剂活性受翻译后机制快速可逆地控制。

2019年1月11日 · Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia–reperfusion (I/R) injury.

Sprouty (SPRY) proteins represent an important class of ligand-inducible inhibitors of RTK-dependent signaling pathways. Here, we investigated the role of SPRY1 in cells of the central nervous system (CNS).

2024年6月30日 · 快速发育生长因子同源蛋白（sprouty，SPRY）作为一种关键的mRNA，是体内受体酪氨酸激酶（receptor protein tyrosine kinase，RTKs）信号传导的抑制剂[1]，参与调控多种疾病发展；其在细胞中表达量的差异性会诱导出不同的细胞表型。