Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

2024年12月24日 · BMP10 (Bone Morphogenetic Protein 10) is a Protein Coding gene. Diseases associated with BMP10 include Myostatin-Related Muscle Hypertrophy and Pulmonary Hemosiderosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

BMP信号通过细胞外（如Noggin）、细胞内（如FKBP12、小RNA、磷酸酶和I-Smads）以及质膜上的共受体（如内皮胶Endoglin）进行调节。 早期发育过程中的许多过程依赖于BMPs信号传导来促进细胞生长、凋亡和分化，BMPs在维持成人组织内稳态方面也发挥着重要作用，如维持关节完整性、启动骨折修复和血管重塑。 由于BMPs在所有器官系统中的不同功能，有人认为BMPs应被称为身体形态发生蛋白。 他们功能的获得或缺失通常会导致明显的缺陷或严重的病理。 例 …

2025年1月4日 · Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1). Forced expression of BMP10 in gastric cancer (GC) cells inhibited its growth and migration, while knocking down the expression of BMP10 in GC cells promoted cell growth, migration, and metastasis.

2024年5月17日 · BMP10 is a newly identified cardiac-specific protein. In recent years, reports have emphasized the effects of BMP10 on myocardial apoptosis, fibrosis and immune response, as well as its synergistic effects with BMP9 in vascular endothelium and role in …

Here we describe an essential role of BMP10 in regulating cardiac growth and chamber maturation. BMP10 null mice display ectopic and elevated expression of p57(kip2) and a dramatic reduction in proliferative activity in cardiomyocytes at E9.0-E9.5.

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。 编码的前原蛋白经过蛋白水解处理生成成熟蛋白，该蛋白与激活素受体样激酶 1 (ALK1) 结合并在心血管发育中发挥重要作用，包括心肌细胞增殖和心脏大小的调节、动脉导管的闭合、血管生成和心室小梁。 [RefSeq 提供，2016 年 8 月] This gene encodes a secreted ligand of the TGF-beta (transforming growth factor …

2019年12月27日 · Bone morphogenetic protein 10 (BMP10) is a cardiac peptide growth factor belonging to the transforming growth factor β superfamily that critically controls cardiovascular development, growth, and maturation. It has been shown that BMP10 elicits its intracellular signaling through a receptor complex …

2025年2月8日 · bone morphogenetic protein 10, BMP-10. GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension. BMP10 functions independently from BMP9 for the development of a proper arteriovenous network.

2024年2月29日 · BMP10（Bone Morphogenetic Protein 10）是一种在生物医药领域中备受关注的蛋白质，属于骨形态发生蛋白家族中的一员。BMP10是一种重组蛋白，其基因位于人类基因组中的7号染色体上，编码了一个含有359个氨基酸的蛋白质。