2008年7月25日 · Type II receptor utilization differed significantly between BMP-2/4 and BMP-6/7. A greater reliance on BMPR2 was observed for BMP-2/4 relative to BMP-6/7, whereas ACVR2A was more critical to signaling by BMP-6/7 than BMP-2/4. Significant differences were also observed for the type I receptors.

肾发育不良（rhd）患者中发现bmp4突变。bmp4和bmp7的适当信号传导是尿道完全发育所必需的。 bmp7已经成为肾脏发育最关键的bmp之一。缺乏bmp7的小鼠除了眼睛缺陷外，还有严重的肾脏缺陷。此外，bmp7信号已被证明对高血压性肾硬化具有保护作用。

BMP4 is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. This particular family member plays an important role in the onset of endochondral bone formation in humans.

bmp-4 在钙化的动脉粥样硬化斑块中差异表达，是动脉粥样硬化血管钙化与正常骨形成机制之间的连接点。 BMP-4 通过其促炎和促动脉粥样硬化作用增加斑块形成，促进氧化应激、内皮功能障碍和成骨分化。

2015年4月14日 · For example, BMP7 is involved in kidney, eye, and limb development; BMP4, 7, and 14 are important for proper reproductive tissue development; BMP2, 3, and 7 contribute to cartilage...

除了从各种动物骨组织中提取骨形成蛋白外,目前已有7种BMP cDNA基因,两种OP (osteogenic protein)cDNA基因被克隆,并在真核细胞表达系统及原核细胞表达系统中进行了表达.现已证实基因工程表达的BMP2,4,5,7具有异位诱导软组织成骨的能力.

Immunocytochemistry revealed expression of BMP-4 and -7 in isolated theca cells whereas granulosa cells and oocytes selectively expressed BMP-6. All three cell types expressed a range of BMP-responsive type-I (BMPRIB, ActRI) and type-II (BMPRII, ActRII, ActRIIB) receptors supporting autocrine/paracrine roles within the follicle.

有证据表明，BMP（尤其是 BMP4/6/7）和 BMP 拮抗剂（尤其是 Gremlin1 和卵泡抑素样蛋白 1）在 IBD 发病机制中发挥重要作用。 在这篇综述中，我们提供了 BMP 和 BMP 拮抗剂在 IBD 发病机制和调节肠道干细胞命运中的参与的最新概述。

Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to promote the regeneration of teeth, periodontal tissue, bone, cartilage, the thymus, hair, neurons, nucleus pulposus, and adipose tissue, as well as the for …

My results demonstrated that BMP4 and BMP6 increased osteoclast size but not osteoclast number; however, BMP7 increased osteoclast number but not size. Secondly I treated mature multinuclear osteoclasts with increasing concentrations of BMP 4, 6 and 7 to determine the effect of BMP on osteoclast activity.