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BMS-3 is a potent LIMK inhibitor with IC50 s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. BMS-3 (Compound 2) causes a dose-dependent reduction in cell count and induces mitotic arrest by increases in total nuclear DNA intensity and histone H3 phosphorylation after 24 h treatment in A549 human lung cancer cells.

BMS-3 (Compound 2) causes a dose-dependent reduction in cell count and induces mitotic arrest by increases in total nuclear DNA intensity and histone H3 phosphorylation after 24 h treatment in A549 human lung cancer cells. BMS-3 inhibits A549 …

BMS-3 是一种 LIMK 抑制剂，高效的 LIMK1 抑制剂和 LIMK2抑制剂。 CAS号 (CAS NO.) 1. 为了您的安全和健康，请穿实验服并戴一次性手套操作。 2. 粉末溶解前请先短暂离心，以保证产 …

BMS-3 是一种高效的 LIMK 抑制剂,抑制 LIMK1 和 LIMK2,IC50 分别为 5 nM 和 6 nM。 在A549人肺癌细胞中处理24小时后,BMS-3 (化合物2)引起细胞计数的剂量依赖性减少并通过总核DNA强度和组蛋白H3磷酸化的增加诱导有丝分裂停滞。 BMS-3抑制A549人肺癌细胞,EC50值为154 nM [1]。 BMS-3用于证明LIMK1直接参与Cofilin的磷酸化。 用1-50μM的BMS-3抑制p-LIMK导致在容量条件下孵育10分钟后p-Cofilin的剂量依赖性降低。 作为对照,精子也在非获能条件下孵育10分钟,这 …

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The initial lead compound BMS-3 is a potent inhibitor of both LIMK activity and tubulin polymerization. In A549 cells, BMS-3 caused a dose-dependent reduction in cell count and induced mitotic arrest as shown by increases in total nuclear DNA intensity and histone H3 phosphorylation after 24 h treatment.

bms-3是limk1有效的抑制剂，limk1活性对于细胞迁移和细胞周期进程是必须的。 立即从AbMole中国订购高品质LIM Kinase抑制剂BMS-3 ！ —更好的抑制剂，金标准的化合物库

ChemicalBook 为您提供BMS-3的化学性质，熔点，沸点，密度，分子式，分子量，物理性质，毒性，结构式，海关编码等信息，同时您还可以浏览BMS-3产品的价格，供应商，贸易商，生产企业和生产厂家，最后BMS-3的中文，英文，用途 CAS cas number cas no可能也是您需要的。