Boc-SPPS: Compatible Linker for the Synthesis of Peptide o ...
2016年1月15日 · On-resin protection of Boc-protected aminoacyl o-aminoanilides is achieved with 2-chlorobenzyl chloroformate. Activation through a peptidyl-benzotriazole intermediate allows for facile conversion to peptide-thioesters for use in native chemical ligation.
Methods, setup and safe handling for anhydrous hydrogen fluoride ...
2015年6月18日 · Boc- and 9-Fluorenylmethoxycarbonyl (Fmoc)-SPPS 4, 7, 8, 9, 10 are key techniques that provide peptides and molecular probes to thousands of biologists and...
多肽固相合成—Fmoc法与Boc法 - 知乎 - 知乎专栏
多肽化学合成方法有两种，即 Fmoc合成法 和 Boc合成法 。 Boc合成法. Boc合成法是采用 TFA （三氟乙酸）可脱除的Boc（叔丁氧羰基）为α-氨基保护基，侧链保护采用苄醇类。
Safe and efficient Boc‐SPPS for the synthesis of glycopeptide‐α ...
The protocol presented here is a modified in situ neutralization Boc-solid phase peptide synthesis employing 10% sulfuric acid/dioxane conditions for intermediate Boc removal and TfOH for the final side-chain deprotection step. These conditions were found to be applicable for the synthesis of acid-labile glycopeptide- -thioesters.
In Situ Neutralization Protocols for Boc-SPPS | SpringerLink
2019年12月27日 · In this chapter, we describe a variation of manual in situ neutralization protocols for Boc-SPPS that are highly effective for the rapid synthesis of peptides with different C-terminal functionalities.
Boc-SPPS: Compatible Linker for the Synthesis of Peptide
2015年12月24日 · A protection strategy is described for the efficient synthesis of peptide o-aminoanilides using in situ neutralization protocols for Boc-SPPS. On-resin protection of Boc-protected aminoacyl o-aminoanilides is achieved with 2-chlorobenzyl chloroformate. Activation through a peptidyl-benzotriazole intermediate allows for facile conversion to ...
Boc-SPPS：合成肽 邻 氨基苯甲酰胺的兼容连接子,Organic Letters
2015年12月24日 · 描述了使用Boc-SPPS的原位中和方案有效合成肽邻氨基苯胺的保护策略。用2-氯苄基氯甲酸酯实现Boc保护的氨基酰基邻氨基苯胺的树脂上保护。通过肽基-苯并三唑中间体的活化使得可以容易地转化为用于天然化学连接的肽-硫酯。作为潜在的硫代酯，除了提供可靠的替代硫代酯树脂的替代品外，肽o-氨基 ...
Solid-Phase Peptide Synthesis - SpringerLink
Boc SPPS is designed primarily for simultaneous cleavage of the peptide anchoring linkage and side-chain protecting groups with strong acid (HF or equivalent), whereas Fmoc SPPS is designed primarily to accomplish the same cleavages …
Boc Solid Phase Peptide Synthesis - ChemPep
Boc Solid Phase Peptide Synthesis (Boc-SPPS) synthesizes peptides on resin using Boc as a temporary protecting group.
【阿拉丁】固相多肽合成——高效策略，革新技术
2024年9月4日 · 固相肽合成技术（spps）是一种革命性的生物化学技术，自20世纪60年代问世以来，已成为合成肽和蛋白质的主要方法。 1963年，罗伯特·布鲁斯·梅里菲尔德（Robert Bruce Merrifield）首次提出了固相肽合成的概念，这一突破性工作不仅极大地提高了肽合成的效率和可控 ...