Since the removal of BPA from commercial products, bisphenol S (BPS) has acted as a substitute. It was thought to be more heat-stable and less disruptive to the endocrine system, but research done in Nancy Wayne’s lab at UCLA shows a striking similarity between the effects of BPS and those of BPA.

Bisphenol S (BPS, dioxydiphenylsulfone) is an organic compound with the formula (HOC6H4)2SO2. It has two phenol functional groups on either side of a sulfonyl group. It is commonly used in curing fast-drying epoxy resin adhesives. It is classified as a bisphenol, and a close molecular analog of bisphenol A (BPA).

Bisphenols are a group of chemical compounds commonly used in the production of plastics to make them strong, durable, and clear. The most well-known bisphenol, Bisphenol A (BPA), is widely used in the manufacture of plastic resins that line food and beverage cans.

In recent years, bisphenol analogues such as bisphenol S (BPS) have come to replace bisphenol A in food packaging and food containers, since bisphenol A (BPA) has been shown to leach into food and water, causing numerous negative health effects.

Bisphenol S (BPS), related to its chemical cousin Bisphenol A (BPA), is an organic compound used to make hard plastic and synthetic fibers. It is commonly used as a replacement for BPA in some types of paper receipts, can be used to lengthen color life in fabrics, and is a food packaging preservative.

In this issue, Boucher et al describe the stimulatory effects of bisphenol S (BPS) on the differentiation and lipid accumulation in human adipocytes. Human exposure to bisphenol A (BPA), and very recently to its close analog BPS, has been associated with widespread health concerns for over 2 decades.

Mar 23, 2025 · Some plastics marketed as “BPA-free” may still contain other bisphenol compounds, such as BPS (Bisphenol S) or BPF (Bisphenol F), which can have similar endocrine-disrupting effects. Recent research suggests that BPS and other bisphenol alternatives may also interfere with hormonal regulation, brain development, and metabolic functions.