2012年1月10日 · Using histologic and protein analyses, and application of a novel forelimb functional assessment, we examined potassium bisperoxo (picolinato) vanadium (bpV [pic])-mediated effects on neuroprotection, functional recovery, and the involvement of Akt/mTOR and autophagic activity following cervical unilateral contusive SCI.

Clear therapeutic efficacy of a phosphatase and tensin homologue (PTEN) inhibitor called bisperoxovanadium (bpV) has been shown in SCI, traumatic brain injury, stroke, and other neurological disease models in both neuroprotection and functional recovery.

2011年1月28日 · This study demonstrates that the PTEN inhibitor, bpv (pic) significantly decreased infarct volume and reduced the number of TUNEL-positive cells. bpv (pic) prevented the injury-induced decrease in phosphorylation of mTOR, and the subsequent decrease in S6.

Many preclinical cellular and animal studies have used PTEN inhibitors to highlight specific disease contexts where acute activation of PI3K/Akt/mTOR pathway might offer therapeutic advantages. In the present study we have re-evaluated first-generation PTEN inhibitors, including established bisperoxo-vanadium (V) complexes (bpVs).

2021年10月11日 · The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic effects of the phosphatase and tensin homolog (PTEN) inhibitor, potassium bisperoxo (picolinato) vanadium (bpV [pic]), in models of neurological injury and demonstrated significant neuroprotective effects on MN survival.

2022年6月29日 · 本综述详细介绍了mTOR的结构、相关通路等，详细介绍了特异性底物如ULK1、TFEB、AKT的结构，并较全面地梳理了目前mTOR的底物，相信可以为研究mTOR的各位提供很好的参考。

2024年8月28日 · In the IgAN mouse model, rapamycin inhibited mTOR, restored autophagy, reduced mesangial IgA deposition, alleviated mesangial cell proliferation, and decreased proteinuria (all P <0.05). In contrast, bpV (phen) activated mTOR, further suppressed autophagy, exacerbated kidney damage, and increased proteinuria (all P <0.05).

2019年9月10日 · PTEN inhibition mediated by bpV (pic) promoted the axonal elongation and initiation abilities of cerebral cortical neurons, as well as the ability of these axons to cross the CSPG border; these effects were mediated via the PTEN/PI3K/Akt/mTOR signaling pathway.

2019年1月23日 · Clear therapeutic efficacy of a phosphatase and tensin homologue (PTEN) inhibitor called bisperoxovanadium (bpV) has been shown in SCI, traumatic brain injury, stroke, and other neurological...

2019年9月9日 · Clear therapeutic efficacy of a phosphatase and tensin homologue (PTEN) inhibitor called bisperoxovanadium (bpV) has been shown in SCI, traumatic brain injury, stroke, and other neurological disease models in both neuroprotection and functional recovery.