Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also …

BET inhibitors are a class of drugs that reversibly bind the bromodomains of Bromodomain and Extra-Terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT, and prevent protein …

2024年12月24日 · BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include Nut Midline Carcinoma and Adolescence-Adult Electroclinical …

In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell …

2022年6月27日 · BRD2/3/4/T是哺乳动物细胞中BET蛋白家族成员，它们均包含两个保守的溴结构域和一个ET结构域，是多种疾病抑制剂的关键靶点。 BRD4通过招募转录延伸因子pTEF-b调 …

2013年9月18日 · Brd2 is specifically localized at promoters of target genes, and our data show that Brd2 interaction with chromatin cannot be explained solely by histone acetylation. Using …

Human BRD2 (originally known as RING3) and mouse Brd2 (originally known at Fsrg1) were the first mammalian BET genes discovered (Beck, Hanson, Kelly, Pappin, & Trowsdale, 1992; …

该基因编码属于 BET (溴结构域和额外末端结构域) 蛋白质家族的转录调节因子。 这种蛋白质在有丝分裂过程中与转录复合物和乙酰化染色质结合，并通过其两个溴结构域选择性地结合组蛋白 …

BRD2 (human BRD2, mouse Brd2) is the founding member of the BET family of double bromodomain-containing genes, which have two tandem bromodomains at the N-terminal …

2008年11月16日 · The human BRD2 proto-oncogene encodes a double bromodomain protein that binds to acetylated histone H4 in chromatin and is located within the MHC class II locus, …

Human BRD2 was first identified as an autophosphorylating nuclear-specific protein in Hela extracts [1]. Recombinant BRD2 expressed in E. coli showed in vitro kinase activity. However, …

BRD2 is considered to be an “epigenetic reader” because its bromodomains binds to acetylated histone protein, thus interpreting the epigenetic landscape and directing its parent …

2017年4月6日 · We find that BRD2, but not BRD4, co-localizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wide. CTCF recruits BRD2 to co-bound sites …

Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also …

BRD2 is a chromatin reader protein that recognizes and binds acetylated histones, specifically H4K5ac and H4K12ac. This binding controls gene expression and chromatin remodeling. It …

2017年3月16日 · In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T …

2007年2月9日 · BRD2 contains two bromodomains (BD1 and BD2), which are considered to be responsible for binding to acetylated chromatin. The BRD2 protein specifically recognizes the …

Brd2 is a member of the bromodomain extra terminal (BET) protein family, which consists of four chromatin-interacting proteins that regulate gene expression. Each BET protein contains two …

We found that the protein BRD2 is an essential node in the cellular response to SARS-CoV-2 infection. BRD2 is required for ACE2 transcription in human lung epithelial cells and …

2012年9月7日 · To investigate whether Brd2 regulates neuronal differentiation through a E2F1 transcriptional factor, which directly binds Brd2 and controls genes expression for cell cycle …