2019年11月13日 · BRM (BRAHMA) is a core, SWI2/SNF2-type ATPase subunit of SWI/SNF chromatin-remodelling complex (CRC) involved in various important regulatory processes including development. Mutations in SMARCA2, a BRM-encoding gene as well as overexpression or epigenetic silencing were found in various human diseases including cancer.

2017年7月14日 · BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling complex, are critical in chromatin structure regulation. Here, we show that the human BRM (hBRM) bromodomain (BRD)...

2025年3月10日 · The significance of this observation is reflected in the fact that both brm and gnc mutants show decreased levels of SOC1 transcript, which is associated with the increase of histone H3 lysine 4 trimethylation level and with decreased DNA methylation levels. This indicates that together with GNC, BRM acts as a repressor of SOC1.

2021年12月28日 · SWI/SNF染色质重塑复合物的主要生物学功能是通过利用其ATPase亚基 (BRM和BRG1)水解ATP获得的能量改变并重塑核小体的组蛋白和DNA之间相互作用，进而影响基因组特定区域的染色质开放程度，从而调节基因表达。 新进的研究表明，SWI/SNF染色质重塑复合体中各亚基编码基因在肿瘤中的总突变频率高达约20%，这些突变可能通过改变编码亚基的活性以及整个复合体功能，从而影响肿瘤发生与发展。

2021年5月13日 · BRG1 is the most frequently mutated Snf2-like ATPase in cancer. In the present study, we have investigated the role of SWI/SNF in genome instability, a hallmark of cancer cells, given its role in...

2021年7月9日 · Several elements in the BRG1/BRM AT-hook-bromodomain are conserved over ~1 billion years. The conserved DNA binding elements make multi-valent contacts with DNA. The conserved linker structurally couples the AT-hook and bromodomain inducing a unique bound state. The BAF chromatin remodeling complex is critical for genome regulation.

2018年11月21日 · SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2), also known as Brahma homologue (BRM), is a Snf2-family DNA-dependent ATPase. BRM and its close homologue Brahma-related gene 1 (BRG1), also known as SMARCA4, are mutually exclusive ATPases of t …

3 天之前 · The core ATPases, BRG1 (SMARCA4) and BRM (SMARCA2) of the canonical (c) BAF (BRG1/BRM-associated factor) complex is a dependency in AML cells, including those harboring FLT3 mutations.

2023年12月1日 · The SWI/SNF complex subunits exhibited varying effects on DNA damage repair. BRM/BRG1 knock-down promoted γH2AX accumulation in heterochromatin through YAP/TAZ. This study provides a novel direction for DNA damage repair and sheds light on the role of SWI/SNF complex in response to DNA damage repair in heterochromatin.

2021年8月8日 · Bromodomains bind to acetylated lysines on histone N-terminal tails and other proteins. The mutually exclusive ATPases of mSWI/SNF complexes, BRG1 and BRM, contain bromodomains with undefined functional importance in skeletal muscle differentiation.