布鲁顿酪氨酸激酶（Bruton’s tyrosine kinase，BTK）是胞浆内非受体型酪氨酸激酶TEC家族中的一员，在B细胞生长发育、增殖分化过程中起着重要作用，同时也是B细胞恶性肿瘤的治疗靶点。

Bruton's tyrosine kinase (BTK) is a TEC kinase with a multifaceted role in B-cell biology and function, highlighted by its position as a critical component of the B-cell receptor signalling pathway. Due to its role as a therapeutic target in several …

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development. BTK contains five different protein interaction domains.

2018年2月19日 · In this review, we discuss the role of BTK in B cell differentiation and B cell malignancies and highlight the importance of BTK inhibition in cancer therapy. Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell ...

2014年3月24日 · Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and functions as an important regulator of cell proliferation and cell...

2024年2月22日 · Bruton酪氨酸激酶（BTK）是一种非受体激酶，在许多B细胞恶性肿瘤中扮演关键的致癌信号传导作用，对白血病细胞的增殖和存活至关重要。 BTK最初在 X连锁遗传无球蛋白血病 （XLA）中被发现缺陷，对B细胞的发育和成熟B细胞的功能均至关重要。 在被发现后不久，BTK被放置在B细胞抗原受体（BCR）下游的信号传导途径中。 最近，针对该激酶的小分子抑制剂已经在动物模型中展现出出色的抗肿瘤活性，并随后在临床研究中得到证实。 特别是口服的不可 …

2018年2月19日 · Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary immunodeficiency X-linked agammaglobulinemia …

2024年11月1日 · Bruton tyrosine kinase (BTK) is a key node mediating signal transduction downstream of the BCR. The advent of BTK inhibitors has revolutionized the treatment landscape...

BTK，即 布鲁顿酪氨酸激酶，是一种非受体酪氨酸激酶，在B淋巴细胞的发育和激活中发挥重要作用。 BTK抑制剂通过抑制BTK的活性来控制肿瘤的生长和转移。 目前市场上有多种BTK抑制剂，如 伊布替尼 、 阿卡替尼 、 泽布替尼 等，主要用于治疗慢性淋巴细胞白血病、 套细胞淋巴瘤 等B淋巴细胞恶性肿瘤。 2BTK抑制剂的种类. 捷帕力®（匹妥布替尼）是世界上第一个被批准用于既往接受过共价BTK抑制剂治疗的套细胞淋巴瘤患者的BTK抑制剂。 （匹妥布替尼100mg和50mg片 …

Bruton tyrosine kinase (BTK) is a key signalling molecule in the B-cell receptor pathway which is important for B-cell proliferation and survival. The development of drugs which inhibit BTK has led to dramatic improvements in the management of B-cell malignancies, difficult-to-treat diseases that primarily affect older populations.