E41K mutation activates Bruton’s tyrosine kinase by stabilizing an ...
2024年1月24日 · We showed that the constitutively active E41K mutation activates BTK by stabilizing the IP 6 -dependent PH-TH dimer. We observed that a downregulating mutation in …
Genetic and biochemical evidence implicates Btk as a key component of several B cell signaling pathways. Activation of Btk by a point mutation (E41K) within the PH domain (Btk*) results in...
E41K Mutation Activates Bruton’s Tyrosine Kinase by ... - bioRxiv
2024年1月23日 · We showed that the constitutively active E41K mutation activates BTK by stabilizing the IP 6 -dependent PH-TH dimer. We observed that a downregulating mutation in …
Constitutive activation of Bruton's tyrosine kinase induces the ...
Here, we report that low-level expression of the E41K or E41K-Y223F Btk mutants was associated with reduced follicular B-cell numbers and significantly increased proportions of B-1 …
We showed that the constitutively active E41K mutation activates BTK by sta-bilizing the IP6-dependent PH-TH dimer. We observed that a downregulating mutation in the PH-TH domain …
Intracellular MHC class II molecules promote TLR-triggered
2011年3月27日 · The data showing that overexpression of the constitutively active mutant Btk (E41k) corrected the lower abundance of proinflammatory cytokines and type I interferons in …
E41K 突变通过稳定肌醇六磷酸依赖性隐形二聚体激活布鲁顿酪氨 …
我们发现，组成型活性 E41K 突变通过稳定 IP6 依赖性 PH-TH 二聚体来激活 BTK。 我们观察到，与 X 连锁无丙种球蛋白血症相关的 PH-TH 结构域 (R28H) 的下调突变通过阻止 PH-TH 二 …
Early Arrest in B Cell Development in Transgenic Mice That Express …
1999年6月1日 · Bruton’s tyrosine kinase (Btk) is a nonreceptor protein kinase that is defective in X-linked agammaglobulinemia in humans and in X-linked immunodeficiency in mice. To study …
E41K mutation activates Bruton’s tyrosine kinase by stabilizing an ...
2024年7月4日 · We showed that the constitutively active E41K mutation activates BTK by stabilizing the IP 6 -dependent PH-TH dimer. We observed that a downregulating mutation in …
Early arrest in B cell development in transgenic mice that
1999年6月1日 · The transgenic expression of wild-type human Btk corrected all X-linked immunodeficiency features in mice carrying a targeted disruption of the Btk gene. In contrast, …