BV2 cells, due to v-raf/v-myc expression, show enhanced metabolism and growth, ideal for research on microglial activation and inflammation. Their expression of specific oncogenes and antigens mirrors macrophages, making them valuable for studying immune responses and disease mechanisms.

BV2 is a mouse derived microglial cell line broadly used in neuroscience research. This immortalized cell line can serve as an in vitro model to study neurodegenerative diseases and associated cell conditions and processes, i.e., neuroinflammation. Besides, BV2 cells are considered an alternative model system for primary microglia.

BV-2 cells are a murine microglial cell line commonly used as a model for studying microglial function and neuroinflammation. They offer a consistent and reproducible system for investigating the immune responses of microglia in the central nervous system.

Mar 15, 2025 · Explore the characteristics, activation methods, and interactions of BV2 cells as a microglial model to study neuroinflammation and cellular responses. Microglial cells are the primary immune responders in the central nervous system, playing a crucial role in neuroinflammation.

Dec 31, 2024 · In this article, we’ve compiled BV2 cell culture methods, common problems, and solutions to help you start your experiments quickly and efficiently. Growth Characteristics of BV2 Cells. 1) Partial adhesion and suspension: The ratio of suspension to adherent cells is not fixed.

Cell type: Microglial cell; CL= CL_0000129. Breed/subspecies: C57BL/6. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. The suitability of BV2 cells as alternative model system for primary microglia cultures or for …

Feb 17, 2025 · Discover essential BV2 cell culture and gene editing methods to enhance your lab's efficiency and research outcomes.

Dec 17, 2023 · To clarify how impaired lipid degradation impacts the immune function of microglia, we here used RNA-sequencing and functional assays related to the immune response to compare wild-type and mutant BV-2 cell lines under basal conditions and upon pro-inflammatory lipopolysaccharide (LPS) activation.

Aug 12, 2020 · BV2 cells are a well-characterized, extensively employed model system for microglia. Studies have demonstrated that BV2 cells are a valid substitute for primary microglia in many experimental settings, including complex cell-cell interaction studies (Henn et al., 2009).

Aug 19, 2021 · BV-2 Cells Derivation and biomarker. BV-2 is a type of microglial cell derived from C57/BL6 murine. The BV2 cells are immortalized by v-raf /v-myc carrying J2 retrovirus. BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level.