HLA Bw4 and Bw6 Epitopes Recognized by Antibodies and …
To describe the structural basis of HLA Bw4 and Bw6 epitopes that are recognized by antibodies and the KIR3DL1 NK cell receptor. Molecular modeling and x-ray crystallography have refined …
Class I HLA Sequence Motifs Determining the Bw4 and Bw6 …
The encoded HLA-B proteins are pivotal in antigen presentation to cytotoxic T cells, and some variants containing a Bw4 motif also serve as ligands to the killer immunoglobulin-like receptors...
HLA-B*44 and the Bw4-80T motif are associated with poor …
HLA-B alleles are associated with outcomes in various pathologies, including autoimmune diseases and malignancies. The encoded HLA-B proteins are pivotal in antigen presentation to …
Polymorphic Sites Away From the Bw4 Epitope that Affect Interaction of Bw4
2008年11月1日 · KIR3DL1 is a polymorphic, inhibitory NK-cell receptor specific for the Bw4 epitope carried by subsets of HLA-A and -B allotypes. The Bw4 epitope is determined by the …
The Bw4 public epitope of HLA-B molecules confers reactivity with ...
These results show that the presence of the Bw4 epitope influences recognition of HLA-B molecules by NK cells that express NKB1, and suggest that the NKB1 molecule may act as a …
HLA-B*44 and the Bw4-80T motif are associated with poor
2023年8月19日 · The encoded HLA-B proteins are pivotal in antigen presentation to cytotoxic T cells, and some variants containing a Bw4 motif also serve as ligands to the killer …
Immunogenicity differences between BW4 subtypes - ScienceDirect
2015年10月1日 · Structural and electrostatic potential differences between Bw4 subtypes appear sufficient to elicit alloimmune responses. Exposure to IALR, the most common Bw4 motif, can …
Conserved and variable residues within the Bw4 motif of HLA-B …
1997年6月1日 · Three types of polymorphism are implicated in formation of the ligand recognized by NKB1: ones shared by Bw4 motifs; ones distinguishing Bw4 motifs; and ones outside the …
HLA-B*44 and the Bw4-80T motif are associated with poor …
HLA-B alleles are associated with outcomes in various pathologies, including autoimmune diseases and malignancies. The encoded HLA-B proteins are pivotal in antigen presentation to …
(PDF) Bw4/Bw6 ON HLA-A AND HLA-C: THE FORGOTTEN
2014年10月1日 · The presence of the Bw4 motif (RIALR, residues 79-83) and Bw6 motif (NLR, residues 80-82) on these HLA-A and HLA-C antigens were verified by inspecting the …
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