BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy. [5][6][7][8][9] BAG proteins compete with Hip-1 for binding to the Hsc70 / Hsp70 ATPase domain and …

2024年12月24日 · BAG3 (BAG Cochaperone 3) is a Protein Coding gene. Diseases associated with BAG3 include Myopathy, Myofibrillar, 6 and Cardiomyopathy, Dilated, 1Hh. Among its related pathways are Cellular responses to stimuli and Cellular response to heat stress.

摘 要:Bcl2 相关永生基因3(BAG3) 被鉴定为抗凋亡和前自噬因子,包含BAG、WW 和PXXP三个结构域。 BAG3与多种蛋白相互作用,被多种信号激活,又能激活多种信号通路,调控多种生理和病理过程,提示开发其特异性抑制剂可能为肿瘤的化学治疗提供候选药物,而开发其特异性激活剂可能为肌肉及神经退行性疾病的防治提供候选药物。 现对人源BAG3的结构特征、相互作用蛋白、信号通路及生物学功能进行综述。 关键词:Bcl2 相关永生基因3;信号通路;伴侣辅助选择性自噬;扩张型心肌 …

2011年4月7日 · Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through BAG domain (110-124 amino acids). BAG3 is the only member of the family to be induced by stressful stimuli, mainly through the activity of heat shock factor 1 on bag3 gene promoter.

2011年4月7日 · Bcl2-associated athanogene 3 (BAG3) protein is a member of BAG family of co-chaperones that interacts with the ATPase domain of the heat shock protein (Hsp) 70 through...

2024年2月23日 · BAG3（BCL2-associated athanogene-3）是一种重要的分子伴侣蛋白，在细胞应激、凋亡和信号转导等生物学过程中发挥着重要作用。 最近，研究人员成功地制备了BAG3的重组蛋白，并对其生物学功能进行了深入的探索和解析。

bag3是一种多功能hsp70伴侣蛋白和抗凋亡蛋白，可通过其c端bag结构域与hsp70的atpase结构域相互作用，在细胞蛋白水解中起着关键的生理作用。 HSP70 / BAG3复合物通过两种主要的蛋白质降解途径（即蛋白酶体降解和巨噬细胞自噬）来调节其选择性，从而决定了大量选择 ...

We describe BAG3 as a quintessential multi-functional protein. It supports autophagy of both misfolded proteins and damaged organelles, inhibits apoptosis, maintains the homeostasis of the mitochondria, and facilitates excitation contraction coupling through the L-type calcium channel and the beta-adrenergic receptor.

2023年3月19日 · We describe BAG3 as a quintessential multi-functional protein. It supports autophagy of both misfolded proteins and damaged organelles, inhibits apoptosis, maintains the homeostasis of the mitochondria, and facilitates excitation contraction coupling through the L-type calcium channel and the beta-adrenergic receptor.

2020年8月1日 · BAG3 protein modulates multiple pathways involved into cell stress response. Apoptosis, autophagy, cytoskeleton dynamics are regulated by BAG3. BAG3 supports cell survival in several tumor types under stressful conditions. Recent advances reported a new paracrine activity of secreted BAG3 on macrophages.