抗凋亡基因代表成员 Bcl-2 是第一个被确认的能对抗细胞凋亡的基因，可编码 Bcl-2α（26 kD）和 Bcl-2β（22 kD）两种蛋白，其中 Bcl-2α 是抑制凋亡作用发挥的主要蛋白 ，为线粒体膜的整合蛋白。在其肽链的 C 末端具有疏水性跨膜（TM）结构域，可通过该疏水区锚定于 ...

Bcl-2 homologous antagonist/killer is a protein which in humans is encoded by the BAK1 gene on chromosome 6. [4] [5] It belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.

bh3蛋白可以与抗凋亡bcl-2蛋白（如 bcl-2、bcl-xl、mcl-1）高亲和力结合，这使得 促凋亡效应蛋白 bak 和 bax 摆脱了抗凋亡 bcl-2 家族成员的束缚。 在这种激活下，BAX和BAK在线粒体外膜中寡聚并形成孔，导致线粒体外膜透化 （MOMP） ，导致 细胞色素 c 从线粒体内膜和外 ...

The pro-apoptotic proteins in the BCL-2 family, including Bax and Bak, normally act on the mitochondrial membrane to promote permeabilization and release of cytochrome c and ROS, that are important signals in the apoptosis cascade.

The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA). BCL-2 and its closest homolog promote cell survival …

Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial outer membrane (MOM) to mediate its permeabilization, which is considered a key step in apoptosis.

2020年4月1日 · The BCL-2 family of proteins control a key checkpoint in apoptosis, that of mitochondrial outer membrane permeabilization or, simply, mitochondrial poration. The family consists of three subgroups: BH3-only initiators that respond to apoptotic stimuli; antiapoptotic guardians that protect against ce …

2023年7月12日 · The BCL-2 family executioner proteins BAX and BAK resemble the guardian proteins, in that they also contain all four BH domains 32 (Fig. 1a) and in their inactive form adopt the typical BCL-2...

2006年6月2日 · In mammals, the multidomain proteins (MDPs) of the Bcl-2 family include Bax, Bak, and Bok. The founding member of the MDP group of Bcl-2-family proteins was discovered by Stanley Korsmeyer...

The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of apoptosis, a form of programmed cell death, at the mitochondrion. [2]