Nature子刊:BAM15的小分子药物可降低小鼠的体内脂
近日，美国弗吉尼亚理工大学的研究人员在 Nature 子刊 Nature Communications 杂志发表题为：Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice …
BAM15 as a mitochondrial uncoupler: a promising therapeutic …
2023年10月11日 · By disrupting the coupling between electron transport and ATP synthesis, BAM15 dissipates the proton gradient, leading to increased mitochondrial respiration and …
BAM15 作为线粒体解偶联剂：多种疾病的有前途的治疗 …
2023年10月11日 · BAM15 是一种选择性线粒体解偶联剂，由于其增强线粒体呼吸和代谢灵活性的能力，已成为一种有前途的治疗剂。 通过破坏电子传输和 ATP 合成之间的耦合，BAM15 消 …
BAM15 as a mitochondrial uncoupler: a promising therapeutic
2023年10月11日 · AMPK responds to BAM15-induced ATP reduction, facilitating glucose uptake and fatty acid oxidation. Concurrently, BAM15 enhances PGC-1α activity, promoting …
BAM15 treats mouse sepsis and kidney injury, linking mortality
2023年2月9日 · BAM15, a chemical uncoupler, dissipates mitochondrial proton gradients without generating mtROS. We injected BAM15 into mice at 0, 6, or 12 hours after cecal ligation and …
BAM15 treats mouse sepsis and kidney injury, linking mortality
2023年2月9日 · We found that (a) BAM15 improved survival and AKI after sepsis, even with a 12-hour treatment delay; (b) levels of 1 DAMP, mtDNA, were diminished by BAM15 treatment in …
Identification of a novel mitochondrial uncoupler that does …
2014年4月1日 · Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less cytotoxic. …
BAM-15 (BAM-15) - 药物靶点：Mitochondrial uncoupling …
BAM15是一种可口服的新的线粒体特异性质子载体解偶联剂，在增加能量消耗方面显示出与DNP相似的效力，此外，BAM15可以增加营养物质的氧化，并在不改变食物摄入量、瘦体重、体温 …
Identification of a novel mitochondrial uncoupler that does not ...
2013年11月28日 · Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less …
Mitochondrial uncoupler BAM15 inhibits artery constriction and …
BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular …