BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. [ 5 ] [ 6 ] [ 7 ] The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and a tandem BRCT domain (residues 568-777).

2024年12月24日 · BARD1 (BRCA1 Associated RING Domain 1) is a Protein Coding gene. Diseases associated with BARD1 include Breast Cancer and Inherited Cancer-Predisposing Syndrome. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.

2025年3月7日 · An inherited BARD1 mutation may affect your options for breast cancer prevention, detection and treatment. FORCE is here to guide you.

2022年9月20日 · In fact, the BARD1 gene is associated with the most aggressive breast cancer subtype, triple-negative breast cancer, according to Massachusetts General Hospital. It’s not known if men with a...

2021年6月11日 · 研究发现，bard1通过识别泛素k63-e64位点，而非普遍存在的i44与i36位点与泛素结合，从而揭示了一种新的泛素识别模式。研究利用mst、emsa和itc等技术对上述作用界面进行了体外实验验证，揭示了bard1识别h4k20me0和h2ak15ub的结构基础。

2022年6月22日 · The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structurally, BARD1 has homologous domains to ...

Gene ID: 580, updated on 8-Feb-2025. This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain.

2020年7月27日 · Sequencing analyses revealed that potentially pathogenic BARD1 variants likely conferred a low-moderate risk to hereditary breast cancer, but this association is inconsistent. Here, we review studies of BARD1 as a cancer predisposing gene and illustrate the challenge of discovering additional cancer risk genes for hereditary breast and/or ...

2020年2月24日 · BRCA1 partners with BRCA1-associated RING domain protein 1 (BARD1) and other tumour suppressor proteins to mediate the initial nucleolytic resection of DNA lesions and the recruitment and ...

BRCA associated RING domain 1 (BARD1) is a gene that encodes a protein that binds to BRCA1 at its N-terminal and functions in regulating cell growth and tumor suppression. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame deletions are observed in cancers such as esophageal cancer ...