Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. [5] BAX is a member of the Bcl-2 gene family. BCL2 family …

促凋亡基因代表成员 Bax，能够编码 α、β、γ、δ、ε、σ 共 6 种 Bax 蛋白亚型。 Bax 基因编码的具有生物学活性的 Baxα（21 kD），是 Bax 基因在细胞中发挥促凋亡作用的主要表达形式。 …

2023年1月30日 · The Bax gene encodes BCL2L4 protein that, upon activation, heterodimerizes with Bcl2 family proteins and alters cellular mitochondria to induce cell death. Bax protein is …

Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major pro-apoptotic member of the Bcl-2 family proteins that control apoptosis in normal and …

2023年12月16日 · Using the inactive BAX dimer structure and a pharmacophore-based drug screen, we identify a small-molecule modulator, BDM19 that binds and activates cytosolic BAX …

2023年1月30日 · The BAX gene (Bcl-2 Associated X-protein) is a pro-apoptotic member of the Bcl-2 gene family; it encodes a 21-kDa protein named BAX-alpha, whose association with Bcl …

We conclude that the steady-state amount of BAX associated with mitochondria can be more critical in promoting cell death than membrane-insertion or higher-order oligomer formation …

2021年11月27日 · Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell death through its lethal activity of permeabilizing the mitochondrial outer …

Bax can accelerate cell cycle entry in T-cells and has recently been shown to have a tumour suppressor function as well as carrying mutations in certain cancers. Bax can form ion …

Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major proapoptotic member of the B-cell lymphoma 2 (Bcl-2) family proteins that control …