Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major pro-apoptotic member of the Bcl-2 family proteins that control apoptosis in normal and cancer cells. Dysfunction of apoptosis renders the cancer cell resistant to treatment as well as promotes tumorigenesis.

2022年3月30日 · 在一项新的小鼠研究中，阿尔伯特·爱因斯坦医学院（Albert Einstein College of Medicine）的科学家们开发了一种新的策略来克服耐药性癌症。 他们的发现提供了对凋亡抵抗机制的见解，以及一种可能有助于克服癌症中凋亡抵抗的潜在新治疗策略。 他们的研究结果发表在 《Nature Communications》 杂志上的一篇题为“Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer”的文章中。 研究人员写道：“BCL-2家族相互作用 …

2005年6月30日 · In cancer cells, induction of Bax initiates cell death; Bax overexpression increases apoptosis induced by chemotherapeutic agents [4]. Huang et al. suggest that Bcl-2 might play a significant role in the development of colorectal carcinoma.

2022年3月7日 · Both survival mechanisms can be overcome by the combination of an orally bioavailable BAX activator, BTSA1.2 with Navitoclax. The combination demonstrates synergistic efficacy in...

Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major proapoptotic member of the B-cell lymphoma 2 (Bcl-2) family proteins that control apoptosis in normal and cancer cells. Dysfunction of apoptosis renders the cancer cell …

2014年9月17日 · Nature Communications - A major proapoptotic mediator, Bax, is expressed in lung cancer and its activity can be regulated by phosphorylation. Here, the authors screen a library of compounds...

2024年7月7日 · Results: BAX was highly expressed in most cancers and was associated with poor prognosis in nine cancer types. In addition, BAX showed significant clinical relevance, and the mRNA expression of BAX was also strongly associated with drug sensitivity of many drugs.

In this study, we present a thorough analysis of BAX gene expression and its implications in a pan-cancer context. Leveraging large-scale genomic datasets and experimental validation, we explore the significance of BAX in the development and progression of various cancer types.

Lower expression of Bax protein in breast cancer cells may suggest the potential way of apoptosis avoidance of tumor cells. Correlations among Bax protein, p53 and caspase-3 are likely associated with active apoptotic mechanism in breast cancer cells expressing Bax protein.

2015年9月23日 · Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major proapoptotic member of the B-cell lymphoma 2 (Bcl-2) family proteins that control apoptosis in normal and cancer cells. Dysfunction of apoptosis renders the cancer cell resistant to treatment as well as promotes tumorigenesis.