Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major pro-apoptotic member of the Bcl-2 family proteins that control apoptosis in normal and …

2022年3月30日 · 在一项新的小鼠研究中，阿尔伯特·爱因斯坦医学院（Albert Einstein College of Medicine）的科学家们开发了一种新的策略来克服耐药性癌症。 他们的发现提供了对凋亡抵 …

2005年6月30日 · In cancer cells, induction of Bax initiates cell death; Bax overexpression increases apoptosis induced by chemotherapeutic agents [4]. Huang et al. suggest that Bcl-2 …

2022年3月7日 · Both survival mechanisms can be overcome by the combination of an orally bioavailable BAX activator, BTSA1.2 with Navitoclax. The combination demonstrates …

Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major proapoptotic member of the B-cell lymphoma 2 (Bcl-2) family proteins that control …

2014年9月17日 · Nature Communications - A major proapoptotic mediator, Bax, is expressed in lung cancer and its activity can be regulated by phosphorylation. Here, the authors screen a …

2024年7月7日 · Results: BAX was highly expressed in most cancers and was associated with poor prognosis in nine cancer types. In addition, BAX showed significant clinical relevance, …

In this study, we present a thorough analysis of BAX gene expression and its implications in a pan-cancer context. Leveraging large-scale genomic datasets and experimental validation, we …

Lower expression of Bax protein in breast cancer cells may suggest the potential way of apoptosis avoidance of tumor cells. Correlations among Bax protein, p53 and caspase-3 are likely …

2015年9月23日 · Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction and a major proapoptotic member of the B-cell lymphoma 2 (Bcl-2) family proteins …