
HMGB1下调的作用:通过抑制神经元细胞自噬和凋亡减轻大鼠脑 …
2022年7月13日 · 在本研究中,给予anti-HMGB1干预,显著减少Beclin1、LC3-Ⅱ、Bax和cleaved caspase-3的表达和显著增加LC3-Ⅰ和Bcl-2的表达,这表明anti-HMGB1可以抑制脑出血大鼠血 …
槲皮素可改善大鼠肺动脉高压: 基于调控HMGB1/RAGE/NF-κB通路
2023年9月19日 · Chronic hypoxia significantly increased the protein expressions of HMGB1 (P<0.01), RAGE, NF-κB and Bcl-2 (P<0.01) and lowered the protein expressions of Bax and …
【双重剑客】HMGB1——炎症反应与癌症的重要靶点 - 知乎
HMGB1(High mobility group box-1 protein,高迁移率族蛋白B1) 是存在于真核细胞核内的非组蛋白染色体结合蛋白,参与DNA损伤修复和基因组稳定性维持。 HMGB1属于 HMG蛋白家 …
High-mobility group box 1 protein (HMGB1): nuclear weapon in
2005年4月1日 · Inhibition of the pro-apoptotic molecule BCL-2-associated X protein (BAX) is associated with release of HMGB1 during infection 112.
高迁移率族蛋白B1(high mobility group box 1 protein, HMGB 1)
高迁移率族蛋白B1 (high mobility group box 1 protein, HMGB 1)是巨噬细胞释放出一种 核蛋白。 HMGB家族有3个成员,即HMGB1、HMGB2和HMGB3,三者在氨基酸序列上有80%的一致 …
HMGB1 and HMGB2 Cell-specifically Down-regulate the p53- and …
Transient transfections revealed that ectopically expressed or endogenous HMGB1 and HMGB2 (antisense strategy) significantly inhibit in vivo both p73α/β- and p53-dependent transactivation …
Role of HMGB1 and its associated signaling pathways in human ...
2023年9月26日 · Yet, they reported that exosomal HMGB1 induced G2/M phase arrest and apoptosis via decrease of Bax and Bcl2 expression through the activation of …
High mobility group box 1 (HMGB1): a pivotal regulator of …
2020年7月13日 · HMGB1 can inhibit the caspase3/9 pathways, releasing proapoptotic initiators (Bax-Bak) and inducing the expression of antiapoptotic proteins (Bcl-2) . For example, HMGB1 …
白B1(high-mobility group box protein 1 ,HMGB1)是 一种极强的炎性介质[4]。气管内给予HMGB1 可 诱发急性肺损伤[5]。动物试验和临床实践证实,机 械通气时,机体HMGB1 的表达水平升 …
Gene expression of RAGE, HMGB1 and BAX as Genetic markers of …
Gene expression of RAGE, HMGB1 and BAX as Genetic markers of diabetic myocardial infarction in population of Pakistan. W. Hameed, N. Sheikh, I. Liaqat, M. Mukhtar, A. Tayyab, F. Azam, …