MOMP, cell suicide as a BCL-2 family business | Cell Death
2017年10月20日 · Once activated, BAX and BAK cause MOMP, leading to the release of proapoptotic IMS proteins. Cytochrome c (Cyt c) engages APAF1 and induces its …
BAX and BAK dynamics control mitochondrial DNA release during …
2022年3月26日 · Specifically, BAX and BAK initiate MOMP by forming hetero- and homo-oligomeric pores in the outer mitochondrial membrane (OMM), in a process that is inhibited by …
Apoptotic stress causes mtDNA release during senescence and
2023年10月11日 · During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die 3. Here we find that MOMP occurring in a subset of …
细胞死亡机制：凋亡 | CST 博客 - Cell Signaling Technology
当具有 bh3 结构域的促凋亡家族成员（如 bad、bid 和 bim）在细胞应激期间通过表达变化或翻译后修饰被激活时，就会触发凋亡。然后促凋亡蛋白 bax 和 bak 诱导线粒体外膜通透 …
Mitochondrial outer membrane permeabilization at the single …
Mitochondrial outer membrane permeabilization (MOMP) is a central event in the intrinsic apoptotic pathway and essential to control the execution of cell death. Here we review current …
Physiological and pharmacological modulation of BAX
2021年11月27日 · Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell death through its lethal activity of permeabilizing the mitochondrial outer …
Bax-mediated mitochondrial outer membrane permeabilization (MOMP …
2008年3月15日 · Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced …
Bax, Bak and beyond — mitochondrial performance in apoptosis
2017年7月29日 · Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the …
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent …
2018年11月27日 · Mechanistically, vioprolides inhibit MCL-1 and BCL2, which in turn triggers BAX/BAK-dependent mitochondrial outer membrane permeabilization (MOMP). Induction of …
Mitochondria and cell death: outer membrane permeabilization
2010年8月4日 · Activation of either BCL-2-associated X protein (BAX) or BCL-2 antagonist or killer (BAK) is essential for MOMP as cells lacking both proteins fail to undergo MOMP and …