RCSB PDB - 1F16: SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
2000年5月18日 · The solution structure of Bax, including the putative transmembrane domain at the C terminus, was determined in order to understand the regulation of its subcellular …
RCSB PDB - 2K7W: BAX Activation is Initiated at a Novel …
2008年8月27日 · BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such …
RCSB PDB - 6EB6: Crystal structure of BAX W139A monomer
2018年8月5日 · BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association. To elicit apoptosis, BAX …
1F16: SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Download Stucture Data? 192 residues, click to see VAST similar structures. * Click molecule labels to explore molecular sequence information. Madej T, Lanczycki CJ, Zhang D, Thiessen …
Apoptosis regulator BAX - Wikipedia
Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. [5] BAX is a member of the Bcl-2 gene family. BCL2 family …
RCSB PDB - 5W63: Crystal structure of channel catfish BAX
2017年6月16日 · BAX and BAK are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. BAX activation requires its translocation from cytosol to …
Allosteric sensitization of proapoptotic BAX - Nature
2017年7月10日 · BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug...
Physiological and pharmacological modulation of BAX - PubMed
Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM). While …
RCSB PDB - 4S0O: Crystal Structure of the Autoinhibited Dimer of …
2015年1月2日 · Following a pro-apoptotic trigger, cytosolic BAX is activated and translocates to the mitochondria to initiate mitochondrial dysfunction and apoptosis. Here, cellular, …
Physiological and pharmacological modulation of BAX
2022年3月1日 · Mechanistic studies of physiological and synthetic BAX modulators have provided important insights into the BAX activation pathway and apoptosis. BAX activators and …