Chemotherapy-induced pyroptosis is mediated by BAK/BAX …
2020年4月24日 · Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial …
Bax siRNA promotes survival of cultured and allografted granule …
2008年3月7日 · In vivo and ex vivo experiments revealed that C2-ceramide increases Bax expression, while PACAP reverses this effect. In vitro tests using cerebellar NPCs …
Transfection of hard-to-transfect primary human macrophages with Bax …
Small interfering RNA (siRNA) is a critical loss-of-function tool for elucidating the role of genes in biomedical studies. The effective use of siRNA needs transfection technology that delivers …
The pro-apoptotic BAX protein influences cell growth and ...
Phase contrast pictures of cells transfected with control lipofectamine alone (Lipo, left panel), control siRNA (Cont. siRNA, middle panel) and BAX siRNA #1 (right panel) suggest a …
Small-molecule Bax agonists for cancer therapy - Nature
2014年9月17日 · We recently identified serine 184 (S184) of Bax as a critical functional switch controlling its proapoptotic activity. Here we used the structural pocket around S184 as a …
Vaccination with dendritic cells transfected with BAK and BAX siRNA ...
In this study, we show that human papillomavirus E7-loaded dendritic cells transfected with BAK/BAX siRNA downregulate Bak and Bax protein expression and become resistant to killing …
Bax siRNA 和 shRNA 质粒 (h) - Santa Cruz Biotechnology
siRNA产品通常包含3-5种目标特异的19-25 nt的siRNA，用于敲除基因表达; 如果需要确认某一种siRNA单独沉默Bax基因效果，可以申请单独购买某种siRNA双链。 适合的对照抗体: Bax: sc …
SignalSilence® Bax siRNA I | Cell Signaling Technology
SignalSilence ® Bax siRNA I from Cell Signaling Technology (CST) allows the researcher to specifically inhibit Bax expression using RNA interference, a method whereby gene expression …
Transfection of hard-to-transfect primary human macrophages with Bax …
Small interfering RNA (siRNA) is a critical loss-of-function tool for elucidating the role of genes in biomedical studies. The effective use of siRNA needs transfection technology that delivers …
Enhancing dendritic cell vaccine potency by combining a BAK/BAX siRNA …
2007年2月21日 · DCs expressing intact E7 or Sig/E7/LAMP-1 became resistant to attack by CD8 + T cells after transfection with BAK/BAX siRNA, leading to enhanced E7-specific T cell …