2017年11月17日 · The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of...

The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of apoptosis, a form of programmed cell death, at the mitochondrion. [2]

2002年9月1日 · The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision.

2023年7月12日 · In this Review, we revisit the most important advances in the field and integrate them into a new structure–function-based classification of the BCL-2 family members that intends to provide a...

Bcel-2家族蛋白（Bcl-x（L），Bcl-2，Mel-1等）是某些生命过程（包括凋亡和自噬）的关键调节因子。 目前，它们被认为是开发新的抗肿瘤疗法的有希望的靶标。

The BCL-2 family, comprised of both pro-apoptotic and anti-apoptotic members, acts as a checkpoint upstream of CASPASES and mitochondrial dysfunction. BID and BAD possess the minimal death domain BH3, and the phosphorylation of BAD connects proximal survival signals to the BCL-2 family.

2019年1月17日 · In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease.

Bcl-2 is a blocker of programmed cell death and apoptosis that contributes to neoplastic cell expansion by preventing cell turnover caused by physiological cell death mechanisms, as opposed to accelerating rates of cell division.

The BCL-2 family, comprised of both pro-apoptotic and anti-apoptotic members, acts as a checkpoint upstream of CASPASES and mitochondrial dysfunction. BID and BAD possess the minimal death domain BH3, and the phosphorylation of BAD connects proximal survival signals to the BCL-2 family.

相信搜索到这篇文章的读者应该知道BCEL是啥，不过还是简要提一下吧：BCEL（Byte Code Engineering Library）原本是Apache Jakarta的一个子项目，目前已成为Apache Commons的一个子项目，主要用于分析、创建、操纵Java class文件。