The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism.

(R)-3-hydroxybutyrate dehydrogenase (BDH; EC 1.1.1.30) is a mitochondrial membrane enzyme with an absolute and specific requirement for phosphatidylcholine, which acts as an allosteric activator of BDH enzymatic activity. BDH has served as a prototype for lipid-requiring enzymes.

2024年12月24日 · BDH1 (3-Hydroxybutyrate Dehydrogenase 1) is a Protein Coding gene. Diseases associated with BDH1 include Disorder Of Keton Body Transport and Chromosome 3Q29 Microduplication Syndrome. Among its related pathways are …

该基因编码短链脱氢酶/还原酶基因家族的成员。 编码的蛋白质形成线粒体膜的需要同源四聚体脂质的酶，并且对磷脂酰胆碱具有特定要求以获得最佳酶活性。 编码的蛋白质催化乙酰乙酸和 …

Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l -glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators are ADP and leucine and inhibitors include GTP, palmitoyl CoA, and ATP.

2023年11月30日 · 3-羟基丁酸脱氢酶1（BDH1）是一种关键的线粒体酶，参与体内的能量代谢过程。 本文旨在探讨BDH1重组蛋白的特性、功能以及其在能量代谢中的作用。 BDH1重组蛋白： 纯度：>90% as determined by SDS-PAGE. 别名：D-beta-hydroxybutyrate dehydrogenase, BDH, MGC2723, MGC4347, MGC9788, SDR9C1. BDH1蛋白的特性. BDH1蛋白是3-羟基丁酸脱氢酶家族的一员，主要在线粒体中发挥作用。 它通过催化3-羟基丁酸的氧化反应，参与酮体的代谢。 …

Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD (P) + to NAD (P)H. It is found in all living organisms serving both catabolic and anabolic reactions.

BDH1 是参与酮体代谢途径的一种关键酶，在能量平衡中发挥着关键作用，尤其是在禁食或低碳水化合物摄入期间。 抑制 BDH1 是调节细胞内代谢通量的一种战略方法，因为它直接影响线粒 …

Glutamate dehydrogenase is an enzyme that facilitates the reversible conversion of 2-oxoglutarate to glutamate by reductive amination. It is encoded by two genes and has different isoenzymes, which may be localized in either the chloroplast or mitochondria.