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BCKDK regulates the activity of branched-chain α-ketoacid dehydrogenase complex (BCKD) through phosphorylation and inactivation. This inactivation results in increased branched-chain amino acids (BCAA), which is seen to reduce oxidative stress; however, having too much BCAA has been proven to be toxic to humans.

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2021年11月29日 · Mutations in the BDKDK gene have been identified in patients with autism spectrum disorders and intellectual disability 39,40. As the brain depends on a constant supply of BCAAs from the...

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BCKDK is an important key regulator of branched-chain ketoacid dehydrogenase complex activity by phosphorylating and so inactivating branched-chain ketoacid dehydrogenases, the rate-limiting enzyme of the branched-chain amino acid metabolism.

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2021年6月14日 · Nature reviews drug discovery杂志最新一期发表文章，展示一个新激酶BCKDK的功能和抑制剂开发现状。 支链酮酸脱氢酶激酶（BCKDK）与多种人类疾病有关。 …

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