PKD epigenetics is the study of somatically heritable changes in DNA methylation, histone modifications and genes encoding epigenetic modifiers by comparison between normal cells and cystic cells with the application of the advanced epigenetic techniques.

In this study, we identified a BET bromodomain (BRD) protein, Brd4, not only as a novel epigenetic regulator of autosomal dominant polycystic kidney disease (ADPKD) but also as a novel client protein of Hsp90. We found that Brd4 was upregulated in Pkd1 mutant mouse renal epithelial cells and tissues. This upregulation of Brd4 appears to result ...

2025年1月10日 · Polycystic kidney disease (PKD) is a genetic disorder marked by numerous cysts in the kidneys, progressively impairing renal function. It is classified into autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD), with ADPKD being more common.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease leading to kidney failure. To date, there is no cure for the disease although there is one approved disease-modifying therapy: tolvaptan.

2019年8月25日 · Pre-trained language models such as BERT have proven to be highly effective for natural language processing (NLP) tasks. However, the high demand for computing resources in training such models hinders their application in practice.

BERT12(teacher)是我们自己的BERTteacher模型的实现。 FT表示在不使用知识蒸馏的情况下对每个数据集进行直接微调。 KD代表使用最原始的知识蒸馏法。 PKD代表我们提出的Patient-KD-Skip方法。结果表明，除了MRPC之外，PKD-Skip几乎优于所有数据集的基线。

2020年11月30日 · 接下来，我们从PKD模型的两个策略说起：PKD-Last 和 PKD-Skip。 1.PKD-Last and PKD-Skip. PKD的本质是从中间层学习知识，但是这个中间层如何去定义，就各式各样了。 比如说，我完全可以定位我只要奇数层，或者我只要偶数层，或者说我只要最中间的两层，等等 ...

Download scientific diagram | pKD46 vector and functional exo, bet & gam genes. from publication: Improvment Of Homologous Recombination efficiency in E.coli | Abstract–Homologous recombination...

Ketogenic dietary interventions (KDIs) are beneficial in animal models of autosomal-dominant polycystic kidney disease (ADPKD). KETO-ADPKD, an exploratory, randomized, controlled trial, is intended to provide clinical translation of these findings (NCT04680780).

2022年1月31日 · The possible beneficial effects of SGLTi on polycystic kidney disease (PKD) are shown with green arrows as they can interfere in multiple pathological processes of PKD by adjustments in metabolism via their glucosuric effects.